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Titolo:
RESPONSES OF RAT STRIATAL NEURONS DURING PERFORMANCE OF A LEVER-RELEASE VERSION OF THE CONDITIONED AVOIDANCE-RESPONSE TASK
Autore:
WHITE IM; REBEC GV;
Indirizzi:
INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI BLOOMINGTON IN 47405
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 616, anno: 1993,
pagine: 71 - 82
SICI:
0006-8993(1993)616:1-2<71:RORSND>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONKEY CAUDATE NEURONS; BASAL GANGLIA; DORSOLATERAL STRIATUM; FUNCTIONAL-PROPERTIES; ANTIPSYCHOTIC-DRUGS; REACTIVE CAPACITY; STARTLE RESPONSE; ANIMAL-MODEL; DOPAMINE; SCHIZOPHRENIA;
Keywords:
CONDITIONED AVOIDANCE RESPONSE; HALOPERIDOL; LEVER-RELEASE; STRIATUM; UNIT ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
I.M. White e G.V. Rebec, "RESPONSES OF RAT STRIATAL NEURONS DURING PERFORMANCE OF A LEVER-RELEASE VERSION OF THE CONDITIONED AVOIDANCE-RESPONSE TASK", Brain research, 616(1-2), 1993, pp. 71-82

Abstract

Neural activity was recorded from 218 sites in the striatum (caudate-putamen and nucleus accumbens) of rats trained on a lever-release version of the conditioned avoidance response (CAR) task, in which an auditory signal elicits a short-latency, forelimb withdrawal. > 80% of these recording sites showed task-related activity, including neurons that responded to the auditory stimulus (signal-related cells), the lever-release (response-related cells), or both of these events (signal/response-related cells). Histological analysis revealed a predominance ofsignal-related neurons in medial striatum, whereas lateral recording sites mainly showed response-related activity. Haloperidol (0.1 mg/kg s1.c.), a widely used neuroleptic that impairs CAR performance, significantly attenuated task-related neural activity without altering the latency of the neural response or spontaneous firing rate. Collectively, these results, which demonstrate the usefulness of the lever-releaseCAR paradigm for assessing striatal function, suggest that the sensory and motor aspects of the CAR task are processed by different striatal regions. Moreover, haloperidol appears to disrupt the striatal processing of both sensory and motor information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:47:45