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Titolo:
AUTORADIOGRAPHIC STUDY OF NEUROSTEROID BINDING-SITES LABELED WITH [S-35] TBPS IN BRAIN OF DIFFERENT SPECIES
Autore:
VINCENS M; DARTOIS E; POPELIER M; MARQUETTE C; MOYSE E; FILLION G; HAOUR F;
Indirizzi:
HOP LARIBOISIERE,2 RUE AMBROISE PARE F-75475 PARIS 10 FRANCE INST PASTEUR F-75724 PARIS 15 FRANCE
Titolo Testata:
Brain research bulletin
fascicolo: 3, volume: 32, anno: 1993,
pagine: 251 - 256
SICI:
0361-9230(1993)32:3<251:ASONBL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROID-HORMONE METABOLITES; GABAA RECEPTOR COMPLEX; RAT-BRAIN; PREGNENOLONE-SULFATE; RECOGNITION SITES; CHANNEL COMPLEX; ALPHA-SUBUNIT; A RECEPTOR; )S-35>TERT-BUTYLBICYCLOPHOSPHOROTHIONATE; PROGESTERONE;
Keywords:
[S-35]-TBPS BINDING; 5-ALPHA-PREGNANE-3-ALPHA-OL-20-ONE; PICROTOXIN; AUTORADIOGRAPHIC TECHNIQUE; MOUSE BRAIN; GUINEA PIG BRAIN; MONKEY CORTEX; HUMAN HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M. Vincens et al., "AUTORADIOGRAPHIC STUDY OF NEUROSTEROID BINDING-SITES LABELED WITH [S-35] TBPS IN BRAIN OF DIFFERENT SPECIES", Brain research bulletin, 32(3), 1993, pp. 251-256

Abstract

Distribution of [S-35]-TBPS binding sites was studied in various structures of brain in mouse and guinea pig and in cortex of monkey and inhippocampus of postmortem human brain. As it is observed for rat brain, high densities of [S-35]-TBPS binding sites were found in layer IV of cortex in the four species, and in thalamus of mouse and guinea pig. Intermediate densities of binding sites were observed in superficialand deep layers of cortex in those four species and in hippocampus ofmouse, guinea pig, and human. In all brain structures studied, 5alpha3alphaP and picrotoxin produced a dose-dependant inhibition of [S-35]-TBPS binding. No significant interregion or interspecies differences could not be detected for IC50 values of 5alpha3alphaP or picrotoxin toinhibit [S-35]-TBPS from its binding sites. In all regions studied, IC50 values were close to 1.5 X 10(-6) M for 5alpha3alphaP and 2.3 X 10(-7) M for picrotoxin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:54:50