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Titolo:
LOCAL INFUSION BALLOON ANGIOPLASTY TO OBVIATE RESTENOSIS COMPARED WITH CONVENTIONAL BALLOON ANGIOPLASTY IN AN EXPERIMENTAL-MODEL OF ATHEROSCLEROSIS
Autore:
STADIUS ML; COLLINS C; KERNOFF R;
Indirizzi:
STANFORD UNIV,MED CTR,DIV CARDIOVASC MED,300 PASTEUR DR,CVRC 287 STANFORD CA 94305
Titolo Testata:
The American heart journal
fascicolo: 1, volume: 126, anno: 1993,
pagine: 47 - 56
SICI:
0002-8703(1993)126:1<47:LIBATO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUMINAL CORONARY ANGIOPLASTY; ENDOTHELIAL-CELLS; INTIMAL HYPERPLASIA; FOLLOW-UP; CATHETER; DETERMINANTS; PRESSURE; INJURY; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M.L. Stadius et al., "LOCAL INFUSION BALLOON ANGIOPLASTY TO OBVIATE RESTENOSIS COMPARED WITH CONVENTIONAL BALLOON ANGIOPLASTY IN AN EXPERIMENTAL-MODEL OF ATHEROSCLEROSIS", The American heart journal, 126(1), 1993, pp. 47-56

Abstract

Balloon angioplasty is an accepted treatment for arterial obstruction; however, a substantial percentage of initially successfully treated lesions recur in the first 4 to 6 months. There is increasing interestin local treatment of lesions undergoing angioplasty to prevent restenosis, and an infusion catheter has been developed for this purpose. This study compared infusion balloon angioplasty by means of saline solution with conventional balloon angioplasty in atherosclerotic iliac arteries of 18 cholesterol-fed New Zealand white rabbits. Values for minimum stenosis diameter assessed angiographically immediately after maximum infusion balloon angioplasty (2.1 +/- 0.6 mm) and after conventional balloon angioplasty (2.3 +/- 0.3 mm, p = NS) were similar. In follow-up studies up to 5 weeks after angioplasty, the angiographic minimum stenosis diameter remained similar in the two treatment groups, butthe histologically assessed intimal area was greater after infusion angioplasty (1.54 +/- 0.92 mm vs 1.02 +/- 0.75 mm in conventionally treated arteries, p = 0.0001). Infusion balloon angioplasty merits further evaluation as a treatment strategy for the simultaneous dilatation of atherosclerotic lesions with delivery of therapeutic agents to minimize restenosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:24:37