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Titolo:
A SEMIEMPIRICAL SCF-MO STUDY ON THE BASE-PAIRING PROPERTIES OF 8-OXOPURINES - SIGNIFICANCE FOR MUTAGENICITY
Autore:
VENKATESWARLU D; LYNGDOH RHD; BANSAL M;
Indirizzi:
INDIAN INST SCI,MOL BIOPHYS UNIT BANGALORE 560012 KARNATAKA INDIA NE HILL UNIV,DEPT CHEM SHILLONG 793003 MEGHALAYA INDIA
Titolo Testata:
Perkin transactions. 2
fascicolo: 3, , anno: 1997,
pagine: 621 - 626
SICI:
0300-9580(1997):3<621:ASSSOT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE DNA DAMAGE; IONIZING-RADIATION; CRYSTAL-STRUCTURE; 8-HYDROXYGUANINE 7,8-DIHYDRO-8-OXOGUANINE; MAGNETIC-RESONANCE; ESCHERICHIA-COLI; MAMMALIAN-CELLS; RAS-GENE; B-DNA; DUPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
D. Venkateswarlu et al., "A SEMIEMPIRICAL SCF-MO STUDY ON THE BASE-PAIRING PROPERTIES OF 8-OXOPURINES - SIGNIFICANCE FOR MUTAGENICITY", Perkin transactions. 2, (3), 1997, pp. 621-626

Abstract

C-8-Oxidised purines like 7-hydro-8-oxoguanine (8OG)and 7-hydro-8-oxoadenine (8OA) are known as products of oxidative DNA damage. Semiempirical molecular orbital calculations at the PM3 SCF-MO level are used to investigate the base-pairing properties of these bases in an attemptto understand their mutagenic properties. A detailed analysis of the base-pairing properties of these bases leads to an identification of the most probable pairing schemes involved in mutagenic base-mispairing. It is suggested that both bases are capable of inducing transversional as well as transitional mutations via base-mispairing. The results presented are largely in consonance with available experimental reports.

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Documento generato il 09/07/20 alle ore 17:12:58