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Titolo:
EXERCISE TRAINING INCREASES GLUT-4 PROTEIN-CONCENTRATION IN PREVIOUSLY SEDENTARY MIDDLE-AGED MEN
Autore:
HOUMARD JA; SHINEBARGER MH; DOLAN PL; LEGGETTFRAZIER N; BRUNER RK; MCCAMMON MR; ISRAEL RG; DOHM GL;
Indirizzi:
E CAROLINA UNIV,SCH MED,DEPT BIOCHEM,HUMAN PERFORMANCE LAB,SPORTS MEDBLDG GREENVILLE NC 27858 E CAROLINA UNIV,SCH MED,DEPT MED GREENVILLE NC 27858
Titolo Testata:
The American journal of physiology
fascicolo: 6, volume: 264, anno: 1993,
parte:, 1
pagine: 896 - 901
SICI:
0002-9513(1993)264:6<896:ETIGPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SKELETAL-MUSCLE; GLUCOSE-TRANSPORT; INSULIN; TISSUE; DENERVATION; EXPRESSION;
Keywords:
INSULIN SENSITIVITY; AGING; GLUCOSE TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Houmard et al., "EXERCISE TRAINING INCREASES GLUT-4 PROTEIN-CONCENTRATION IN PREVIOUSLY SEDENTARY MIDDLE-AGED MEN", The American journal of physiology, 264(6), 1993, pp. 896-901

Abstract

The purpose of this study was to determine if 14 wk of exercise training would increase insulin-sensitive glucose transporter protein (GLUT-4) concentration in skeletal muscle of previously sedentary middle-aged men (47.2 +/- 1.3 yr; n = 13). Muscle samples (lateral gastrocnemius) and insulin action [insulin sensitivity index (ISI), minimal model]were obtained in the sedentary condition and 48 h after the final training bout. GLUT-4 protein concentration increased (P < 0.001, 2,629 +/- 331 to 4,140 +/-391 absorbance units/100 mug protein) with exercisetraining by 1.8-fold. ISI increased by twofold (P < 0.05, 2.1 +/- 0.5to 3.4 +/-0.7 S(I) x 10(5) min/pM) with training. The percentage of GLUT-4 rich type IIa muscle fibers increased by almost-equal-to 10% (P < 0.01), which may have contributed to the elevation in transporter protein. GLUT-4 concentration and citrate synthase activity (1.7-fold, P< 0.001) also increased by similar increments. These findings indicate that GLUT-4 protein concentration is elevated in middle-aged individuals with exercise training.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:48:48