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Titolo:
TISSUE-SPECIFIC ALTERNATIVE RNA PROCESSING IN CALCITONIN CALCITONIN-GENE-RELATED PEPTIDE GENE-EXPRESSION
Autore:
EMESON RB; YEAKLEY JM;
Indirizzi:
VANDERBILT UNIV,MED CTR,SCH MED,DEPT PHARMACOL NASHVILLE TN 37232 UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093
Titolo Testata:
Cellular physiology and biochemistry
fascicolo: 3-4, volume: 3, anno: 1993,
pagine: 181 - 196
SICI:
1015-8987(1993)3:3-4<181:TARPIC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRE-MESSENGER-RNA; MAMMALIAN-CELLS; ACETYLCHOLINE-RECEPTOR; SPLICING INVITRO; BRAIN PEPTIDES; LARIAT RNAS; RAT; PRECURSORS; TRANSCRIPTION; GROWTH;
Keywords:
CALCITONIN; CALCITONIN-GENE-RELATED PEPTIDE; NEUROPEPTIDES; POSTTRANSCRIPTIONAL PROCESSING; SPLICING, ALTERNATIVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Emeson e J.M. Yeakley, "TISSUE-SPECIFIC ALTERNATIVE RNA PROCESSING IN CALCITONIN CALCITONIN-GENE-RELATED PEPTIDE GENE-EXPRESSION", Cellular physiology and biochemistry, 3(3-4), 1993, pp. 181-196

Abstract

The alternative splicing of messenger RNA (mRNA) precursors represents a common mechanism for increasing the flexibility of eukaryotic geneexpression by the generation of structurally distinct, developmentally regulated and tissue-specific protein isoforms. The calcitonin/calcitonin-gene-related peptide (CGRP) primary RNA transcript undergoes tissue-specific alternative processing, resulting in the differential production of calcitonin mRNA in thyroid C cells and CGRP mRNA in neuronsof the central and peripheral nervous systems. The calcitonin/CGRP gene provides an excellent model for examining the regulation of cell-specific alternative RNA processing events in complex transcription units expressed within the neuroendocrine system. Initial studies attempting to delineate the biochemical events involved in the regulation of these cellular processes have taken advantage of a number of molecular biological techniques including expression of the calcitonin/CGRP transcription unit in transgenic mice, tissue culture model systems that mimic the alternative RNA processing choices made by tissues in vivo and the development of in vitro splicing systems. It is anticipated thatcombinations of these experimental approaches will allow the definition of biochemical processes and the isolation of the cellular machinery involved in the regulation of cell-specific RNA processing events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:53:10