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Titolo:
MOLECULAR-CLONING, EXPRESSION, AND GENE LOCALIZATION OF A 4TH MELANOCORTIN RECEPTOR
Autore:
GANTZ I; MIWA H; KONDA Y; SHIMOTO Y; TASHIRO T; WATSON SJ; DELVALLE J; YAMADA T;
Indirizzi:
UNIV MICHIGAN,MED CTR,DEPT SURG ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT INTERNAL MED ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT PHYSIOL ANN ARBOR MI 48109 UNIV MICHIGAN,MED CTR,DEPT PSYCHIAT ANN ARBOR MI 48109
Titolo Testata:
The Journal of biological chemistry
fascicolo: 20, volume: 268, anno: 1993,
pagine: 5174 - 5179
SICI:
0021-9258(1993)268:20<5174:MEAGLO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE STIMULATING HORMONE; HIGHLY EFFICIENT; ALPHA-MSH; DNA; HYBRIDIZATION; PEPTIDES; PRODUCTS; SYSTEM; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
I. Gantz et al., "MOLECULAR-CLONING, EXPRESSION, AND GENE LOCALIZATION OF A 4TH MELANOCORTIN RECEPTOR", The Journal of biological chemistry, 268(20), 1993, pp. 5174-5179

Abstract

The recent cloning of three melanocortin receptors suggests an unexpected diversity in this family of seven transmembrane G-protein linked receptors. Herein, we report the cloning, expression, and gene localization of a fourth human melanocortin receptor, the melanocortin-4 receptor. By Northern blot analysis and in situ hybridization, this receptor is expressed primarily in the brain, but its expression is notably absent in the adrenal cortex, melanocytes, and placenta. Agonist stimulation of COS-1 cells transiently transfected and L-cells permanently transfected with the coding region of the cloned melanocortin-4 receptor leads to increases in intracellular cyclic 3',5'-adenosine monophosphate. The profile of the responses of the melanocortin-4 receptor to different melanocortins distinguishes it from melanocortin receptors previously described. Using the technique of fluorescent in situ hybridization, the gene encoding the melanocortin-4 receptor was localized to chromosome 18 (q21.3).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:39:05