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Titolo:
EVALUATION OF THE COMBINATION EFFECT OF DIFFERENT ANTIVIRAL COMPOUNDSAGAINST HIV IN-VITRO
Autore:
SORENSEN AM; NIELSEN C; MATHIESEN LR; NIELSEN JO; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK STATENS SERUM INST,DEPT VIROL DK-2300 COPENHAGEN DENMARK
Titolo Testata:
Scandinavian journal of infectious diseases
fascicolo: 3, volume: 25, anno: 1993,
pagine: 365 - 371
SICI:
0036-5548(1993)25:3<365:EOTCEO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; SYNERGISTIC INHIBITION; REPLICATION INVITRO; DEXTRAN SULFATE; ZIDOVUDINE; INFECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Sorensen et al., "EVALUATION OF THE COMBINATION EFFECT OF DIFFERENT ANTIVIRAL COMPOUNDSAGAINST HIV IN-VITRO", Scandinavian journal of infectious diseases, 25(3), 1993, pp. 365-371

Abstract

3'-azido-3'deoxythymidine (AZT), a clinically used anti-HIV compound,was evaluated for antiviral effect on HIV infection in combination with other antiviral compounds in vitro. Interactions were evaluated by the median-effect principle and the isobologram technique. Synergisticeffect was obtained by combining many evaluated antiviral agents withAZT. We observed a difference in the degree of synergism depending onthe evaluated compound; the results indicate that compounds with the same target in the viral replicative cycle (ddI: 2',3'-dideoxyinosine,didanosine; d4T: 2',3'-dideoxy-2',3'-didehydrothymidine stavodine; TIBO: tetrahydro-imidazole-benzodiazepin) had a synergistic effect at all concentrations, agents that disturb the infectivity of virus (CAS: Castanospermine; AME: Amphotericin B Methyl Ester) exerted a strong synergistic effect at low concentrations, and finally compounds interfering with the adhesion/penetration process of virus (ConA: Concanavalin A; DS: dextran sulfate) were most potent with AZT when used in rather high concentrations. At this moment in the HIV epidemic, these observations suggest that combinations of antiviral compounds should be evaluated in clinical trials, with the major emphasis on nucleoside analogues and compounds influencing the infectivity of the virus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:41:52