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Titolo:
ERADICATION OF HELICOBACTER-PYLORI - AN OBJECTIVE ASSESSMENT OF CURRENT THERAPIES
Autore:
PENSTON JG; MCCOLL KEL;
Indirizzi:
UNIV GLASGOW,WESTERN INFIRM,GARDINER INST,DEPT MED & THERAPEUT GLASGOW G11 6NT LANARK SCOTLAND UNIV GLASGOW,WESTERN INFIRM,GARDINER INST,DEPT MED & THERAPEUT GLASGOW G11 6NT LANARK SCOTLAND SCUNTHORPE GEN HOSP SCUNTHORPE ENGLAND
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 3, volume: 43, anno: 1997,
pagine: 223 - 243
SICI:
0306-5251(1997)43:3<223:EOH-AO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
OMEPRAZOLE PLUS AMOXICILLIN; DUODENAL-ULCER PATIENTS; COLLOIDAL BISMUTH SUBCITRATE; HIGH-DOSE OMEPRAZOLE; TERM TRIPLE THERAPY; RANDOMIZED CONTROLLED TRIAL; 12-MONTH FOLLOW-UP; EPITHELIAL-CELL PROLIFERATION; DOUBLE-BLIND TRIAL; PEPTIC-ULCER;
Keywords:
HELICOBACTER PYLORI; ANTIBIOTICS; PROTON PUMP INHIBITOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
369
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Penston e K.E.L. Mccoll, "ERADICATION OF HELICOBACTER-PYLORI - AN OBJECTIVE ASSESSMENT OF CURRENT THERAPIES", British journal of clinical pharmacology, 43(3), 1997, pp. 223-243

Abstract

The purpose of the present review was to determine objectively the optimal treatment for the eradication of H. pylori amongst the currentlyused regimens. A comprehensive literature search provided a data-baserelating to the following treatments: dual therapy with an anti-secretory drug plus either amoxycillin or clarithromycin; standard triple therapy, with or without additional anti-secretory drugs; proton pump inhibitor triple therapy; and H-2-receptor antagonist triple therapy. Emphasis was placed on intention-to-treat analyses of eradication ratesusing all of the available evidence. The criteria used to select the optimal treatment were efficacy (eradication rates), frequency of side-effects, simplicity of the regimen (number of tablets per day and duration of treatment) and cost. The analysis showed that proton pump inhibitor triple therapy (that is, a proton pump inhibitor plus any two of amoxycillin, clarithromycin or a nitroimidazole) was the preferred treatment for the eradication of H, pylori. In particular, the 1-week, low-dose regimen with omeprazole plus clarithromycin plus tinidazole produced the highest eradication rates (>90%) with the lowest frequencyof side-effects and at only modest cost.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:23:40