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Titolo:
PROBABILITY OF ALAMETHICIN CONDUCTANCE STATES VARIES WITH NONLAMELLARTENDENCY OF BILAYER PHOSPHOLIPIDS
Autore:
KELLER SL; BEZRUKOV SM; GRUNER SM; TATE MW; VODYANOY I; PARSEGIAN VA;
Indirizzi:
NIH,BLDG 10,ROOM 9B-07 BETHESDA MD 20892 NIH,BLDG 10,ROOM 9B-07 BETHESDA MD 20892 PRINCETON UNIV,DEPT PHYS PRINCETON NJ 08544 RUSSIAN ACAD SCI,ST PETERSBURG NUCL PHYS INST MOSCOW 188350 RUSSIA OFF NAVAL RES ARLINGTON VA 22217
Titolo Testata:
Biophysical journal
fascicolo: 1, volume: 65, anno: 1993,
pagine: 23 - 27
SICI:
0006-3495(1993)65:1<23:POACSV>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLACK LIPID-MEMBRANES; INTRINSIC CURVATURE; PHASE; CHANNELS; TRANSITIONS; BEHAVIOR; PACKING;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Keller et al., "PROBABILITY OF ALAMETHICIN CONDUCTANCE STATES VARIES WITH NONLAMELLARTENDENCY OF BILAYER PHOSPHOLIPIDS", Biophysical journal, 65(1), 1993, pp. 23-27

Abstract

With few exceptions, membrane lipids are usually regarded as a kind of filler or passive solvent for membrane proteins. Yet, cells exquisitely control membrane composition. Many phospholipids found in plasma membrane bilayers favor packing into inverted hexagonal bulk phases. Itwas suggested that the strain of forcing such lipids into a bilayer may affect membrane protein function, such as the operation of transmembrane channels. To investigate this, we have inserted the peptide alamethicin into bilayer membranes composed of lipids of empirically determined inverted hexagonal phase ''spontaneous radii'' Ro, which will have expectably different degrees of strain when forced into bilayer form. We observe a correlation between measured Ro and the relative probabilities of different conductance states. States of higher conductanceare more probable in dioleoylphosphatidylethanolamine, the lipid of highest curvature, 1/Ro, than in dioleoylphosphatidylcholine, the lipidof lowest curvature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 07:40:16