Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SITES AND TYPES OF P53 MUTATIONS IN AN UNSELECTED SERIES OF COLORECTAL CANCERS IN THE NETHERLANDS
Autore:
VANDENBROEK MH; RENAULT B; FODDE R; VERSPAGET H; GRIFFIOEN G; KHAN PM;
Indirizzi:
LEIDEN UNIV,SYLVIUS LAB,MGC,DEPT HUMAN GENET,POB 9500 2300 RA LEIDEN NETHERLANDS LEIDEN UNIV,MED CTR,DEPT GASTROENTEROL 2300 RA LEIDEN NETHERLANDS
Titolo Testata:
Anticancer research
fascicolo: 3, volume: 13, anno: 1993,
pagine: 587 - 592
SICI:
0250-7005(1993)13:3<587:SATOPM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL POLYPOSIS-COLI; TUMOR-ANTIGEN; GEL-ELECTROPHORESIS; GENE-MUTATIONS; ALLELE LOSS; CELLS; DNA; CARCINOMA; PROTEIN; OCCUR;
Keywords:
P53 MUTATIONS; DGGE; DOUBLE MUTATIONS; COLORECTAL CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Vandenbroek et al., "SITES AND TYPES OF P53 MUTATIONS IN AN UNSELECTED SERIES OF COLORECTAL CANCERS IN THE NETHERLANDS", Anticancer research, 13(3), 1993, pp. 587-592

Abstract

An unselected series of colorectal adenocarcinomas together with their corresponding normal mucosa, derived from 24 Dutch patients, was investigated for the loss of a marker mapping close to the region of p53 on chromosome 17p and for mutations in exons 5, 6, 7 and 8 of the p53 gene. The observed loss of heterozygosity of the marker on chromosome 17p was 36% of the informative cases, while 58% of the tumors contained a mutation in p53. This might be an indication that the mutation in p53 precedes the loss involving p53 on the homologous chromosome. Fourtumors showed the presence of two different missense mutations in thep53 gene; in one of them the mutations involved the first two nucleotides of one and the same codon, while in a second case they were foundwithin the same exon. In the remaining two cases the assessment of their situation, cis or trans, was not feasible. Six of the 18 mutationsobserved during this study were base transversions, including 3 G->T substitutions. The hotspot codons 248, 273 and 282, were found to be involved in a third of the mutations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:41:37