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Titolo:
PROSTANOID CASCADE INHIBITION PREVENTS CARDIOVASCULAR AND ADRENOCORTICOTROPIC RESPONSES TO MINERAL ACID INFUSION
Autore:
CUDD TA; WOOD CE;
Indirizzi:
UNIV FLORIDA,DEPT PHYSIOL,BOX J-274 JHMHC GAINESVILLE FL 32610
Titolo Testata:
The American journal of physiology
fascicolo: 6, volume: 264, anno: 1993,
parte:, 2
pagine: 1235 - 1241
SICI:
0002-9513(1993)264:6<1235:PCIPCA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-HYPERTENSION; METABOLIC-ACIDOSIS; PLASMA ACTH; PH; PROSTAGLANDIN-E2; INTERLEUKIN-1; THROMBOXANE; RESPIRATION; RELEASE; SHEEP;
Keywords:
THROMBOXANE-A2; ADRENOCORTICOTROPIC HORMONE; CORTISOL; PROSTAGLANDIN-E2; PROSTAGLANDIN-I2; LEUKOTRIENES; CYCLOOXYGENASE INHIBITOR; FLUNIXIN; INTERLEUKIN-1-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Cudd e C.E. Wood, "PROSTANOID CASCADE INHIBITION PREVENTS CARDIOVASCULAR AND ADRENOCORTICOTROPIC RESPONSES TO MINERAL ACID INFUSION", The American journal of physiology, 264(6), 1993, pp. 1235-1241

Abstract

Mineral acid infusion is used to investigate the effects of acidemia on the cardiovascular and respiratory systems. Previous studies have shown that small infusions of HCl increase mean arterial pressure (MAP), adrenocorticotropic hormone (ACTH), and cortisol without producing acidemia. We infused 1 meq/min of 1 N HCl intravenously into chronically catheterized conscious sheep with or without pretreatment with 1.1 mg/kg flunixin-N-methylglucamine, a cyclooxygenase inhibitor (n = 6). Acid infusion resulted in significant increases in heart rate (83 +/- 5to 94 +/- 7 beats/min), MAP (84 +/-3 to 104 +/- 6 mmHg), ACTH (97 +/-23 to 285 +/- 101 pg/ml), cortisol (20 +/- 3 to 37 +/- 16 ng/ml), sodium (149.5 +/- 0.8 to 150.6 +/- 1.3 meq/l), potassium (3.96 +/- 0.09 to 4.31 +/- 0.19 meq/l), and thromboxane (Tx) B2 (stable metabolite of TxA2) (147 +/- 78 to 2,304 +/- 1,213 pg/ml), whereas these changes were prevented by flunixin. Plasma concentrations of 6-ketoprostaglandin F1alpha (stable metabolite of prostacyclin), prostaglandin E2, interleukin-1alpha, and hematocrit did not change in either group. Arterial pH decreased, whereas arterial partial pressure of CO2 increased significantly in both groups. Arterial partial pressure of O2 declined in both groups, but the decrease was significantly greater in the group notreceiving flunixin. We conclude that a cyclooxygenase metabolite, most likely TxA2, mediates the MAP, heart rate, ACTH, and cortisol responses to mineral acid infusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:51:04