Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FACTORS CONFOUNDING BLOCKADE OF CARDIAC AFFERENTS BY INTRAPERICARDIALPROCAINE IN CONSCIOUS RABBITS
Autore:
EVANS RG; HAYES IP; LUDBROOK J; VENTURA S;
Indirizzi:
UNIV MELBOURNE,ROYAL MELBOURNE HOSP,DEPT SURG,CLIN SCI BLDG PARKVILLEVIC 3052 AUSTRALIA UNIV MELBOURNE,ROYAL MELBOURNE HOSP,DEPT SURG,CLIN SCI BLDG PARKVILLEVIC 3052 AUSTRALIA
Titolo Testata:
The American journal of physiology
fascicolo: 6, volume: 264, anno: 1993,
parte:, 2
pagine: 1861 - 1870
SICI:
0002-9513(1993)264:6<1861:FCBOCA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BARORECEPTORS; UNANESTHETIZED RABBITS; HEMODYNAMIC-RESPONSE; SIMULATED HEMORRHAGE; REVERSIBLE BLOCKADE; NERVE BLOCKADE; RELATIVE ROLES; AWAKE RABBITS; RECEPTORS; VASOPRESSIN;
Keywords:
CARDIAC NERVES; HYPOVOLEMIA; PHENYLBIGUANIDE; PHRENIC NERVE; RESPIRATORY DEPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Evans et al., "FACTORS CONFOUNDING BLOCKADE OF CARDIAC AFFERENTS BY INTRAPERICARDIALPROCAINE IN CONSCIOUS RABBITS", The American journal of physiology, 264(6), 1993, pp. 1861-1870

Abstract

Intrapericardial procaine has been used by several groups to block cardiac afferent nerves to study effects of cardiogenic reflexes. In eight conscious rabbits, procaine (17-113 mg ipc; median 32) blocked cardiac efferents. Procaine (17-113 mg ipc; median 39) abolished the reflex depressor effects of the cardiac C-fiber excitant 1-phenylbiguanide (PBG), and in four of eight rabbits prevented the hypotensive phase 2 of acute central hypovolemia, which has been attributed to a signal from the heart. However, in three of the rabbits respiratory incoordination and blood gas abnormalities developed. In another study of four rabbits, procaine (165-335 mg ipc; median 235) invariably caused phrenicnerve blockade and underventilation. In three rabbits, after intrapericardial (250 mg) or subcutaneous (50 mg) procaine, plasma procaine levels rose to 9.4 and 4.8 mug/ml, respectively. During intravenous infusion of procaine, the PBG chemoreflex was abolished at plasma levels >3.1 mug/ml, and phase 2 of acute hypovolemia at levels greater-than-or-equal-to 4.3 mug/ml. There is a narrow margin between a dose of intrapericardial procaine that blocks cardiac nerves and one that can produce confounding effects from phrenic nerve blockade or absorption into the bloodstream.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:37:37