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Titolo:
CHRONIC ETHANOL-CONSUMPTION DECREASES THE PHORBOL ESTER BINDING TO MEMBRANAL BUT NOT CYTOSOLIC PROTEIN-KINASE-C IN RAT-BRAIN
Autore:
PANDEY SC; DWIVEDI Y; PIANO MR; SCHWERTZ DW; DAVIS JM; PANDEY GN;
Indirizzi:
ILLINOIS STATE PSYCHIAT INST,1153 N LAVERGNE AVE CHICAGO IL 60651 ILLINOIS STATE PSYCHIAT INST,1153 N LAVERGNE AVE CHICAGO IL 60651 UNIV ILLINOIS,COLL MED CHICAGO IL 60680
Titolo Testata:
Alcohol
fascicolo: 4, volume: 10, anno: 1993,
pagine: 259 - 262
SICI:
0741-8329(1993)10:4<259:CEDTPE>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHOINOSITIDE HYDROLYSIS; RECEPTOR; DIACYLGLYCEROL; TRISPHOSPHATE; FEATURES; CORTEX;
Keywords:
CHRONIC ETHANOL; PROTEIN KINASE-C; [H-3]-PHORBOL 12,13 DIBUTYRATE BINDING; BRAIN (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
S.C. Pandey et al., "CHRONIC ETHANOL-CONSUMPTION DECREASES THE PHORBOL ESTER BINDING TO MEMBRANAL BUT NOT CYTOSOLIC PROTEIN-KINASE-C IN RAT-BRAIN", Alcohol, 10(4), 1993, pp. 259-262

Abstract

We examined the effect of 60 days of ethanol treatment on protein kinase C (PKC) in membrane and cytosolic fractions of the rat cerebral cortex. Membranal and cytosolic PKC were determined by binding techniqueusing [H-3]-phorbol 12,13 dibutyrate (PDBU) as radioligand and phorbol 12-myristate 13-acetate (PMA) as displacer. Chronic ethanol consumption resulted in a decrease in the maximum number of binding sites (B(max) of [H-3]-PDBU binding to membranal PKC without significant change in the apparent dissociation constant (K(D)) in the rat cortex. We also observed that chronic ethanol consumption had no significant effect on B(max) or K(D) of [H-3]-PDBU binding to cytosolic PKC in the rat cerebral cortex. These results suggest that chronic ethanol consumption leads to the down-regulation of brain PKC associated with membrane butnot with cytosol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:36:03