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Titolo:
IMMUNE DEFENSE AND EOSINOPHILIA IN CONGENITALLY IGE-DEFICIENT SJA-9 MICE INFECTED WITH ANGIOSTRONGYLUS-COSTARICENSIS
Autore:
WATANABE N; ISHIWATA K; KANEKO S; OKU Y; KAMIYA M; KATAKURA K;
Indirizzi:
JIKEI UNIV SCH MED,DEPT PARASITOL,MINATO KU TOKYO 105 JAPAN HOKKAIDO UNIV,FAC VET MED,DEPT PARASITOL SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Parasitology research
fascicolo: 5, volume: 79, anno: 1993,
pagine: 431 - 434
SICI:
0932-0113(1993)79:5<431:IDAEIC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANAPHYLACTIC REACTIONS; TRICHINELLA-SPIRALIS; SJA/9 MICE; ANTIBODY; SUPPRESSION; RATS; CANTONENSIS; RESISTANCE; SERUM;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
N. Watanabe et al., "IMMUNE DEFENSE AND EOSINOPHILIA IN CONGENITALLY IGE-DEFICIENT SJA-9 MICE INFECTED WITH ANGIOSTRONGYLUS-COSTARICENSIS", Parasitology research, 79(5), 1993, pp. 431-434

Abstract

The roles of IgE in protective immunity and eosinophilia in Angiostrongylus costaricensis infection were examined by comparing IgE-deficient SJA/9 mice and IgE-prodcuing SJL/J mice. In primary infection, mean total IgE levels increased to a maximum of 390 ng/ml, which was more than 10 times greater than the 29 ng/ml measured preinfection in SJL/J mice but less than the 10 ng/ml found in SJA/9 mice throughout the experiment. Immune defense as determined by recovery of adult worms and eosinophilia were similar in SJL/J and SJA/9 mice. Protective immunity was induced by infection with A. costaricensis followed by treatment with levamisole for 4-6 days postinfection. After the challenge infection, the numbers of adult worms and eosinophils in SJA/9 mice were not significantly different from those in SJL/J mice. Anti-A. costaricensis IgE antibody was not detected in either strain of mice during the experiment. These results indicate that A. costaricensis infection induced the production of IgE not specific for parasite antigens in IgE-producing mice. Potentiated nonspecific IgE played no significant role inimmune defense and eosinophilia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:50:21