Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MOLECULAR-CLONING OF 2 RECEPTORS FROM RAT-BRAIN WITH HIGH-AFFINITY FOR SALMON-CALCITONIN
Autore:
ALBRANDT K; MULL E; BRADY EMG; HERICH J; MOORE CX; BEAUMONT K;
Indirizzi:
AMYLIN PHARMACEUT INC,DEPT PHARMACOL,9373 TOWNE CTR DR,SUITE 250 SAN DIEGO CA 92121
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 325, anno: 1993,
pagine: 225 - 232
SICI:
0014-5793(1993)325:3<225:MO2RFR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2 DOPAMINE RECEPTOR; GENE-RELATED PEPTIDE; PROTEIN; SITES; AMPLIFICATION; EXPRESSION; POLYMERASE; SECRETION; PRIMER; CDNA;
Keywords:
CALCITONIN; RECEPTOR; CLONING; PCR; EXPRESSION; RAT BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
K. Albrandt et al., "MOLECULAR-CLONING OF 2 RECEPTORS FROM RAT-BRAIN WITH HIGH-AFFINITY FOR SALMON-CALCITONIN", FEBS letters, 325(3), 1993, pp. 225-232

Abstract

Two receptors with high affinity for salmon calcitonin were cloned from the nucleus accumbens region of rat brain. The deduced 479 amino acid sequence of cDNA clone L2175-D20 (designated C1a receptor) is 78% and 66% identical with those reported for human and porcine calcitonin receptors, respectively. Clone U3237-A2 codes for a receptor (designated C1b) that is identical to C1a except fora 37 aminoacid insert in the second extracellular domain. COS-7 cells transfected with either transcript bound [I-125]salmon calcitonin with high affinity (K(d) = 8 pMfor C1a; K(d) = 48 pM for C1b) and responded to salmon calcitonin with increases in cAMP. Tissue distribution studies revealed C1a transcript in rat brain, skeletal muscle, kidney and lung, whereas C1b was predominantly found in brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:09:33