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Titolo:
TRACHEAL VASCULAR DILATATION ELICITED BY VAGAL NERVE-STIMULATION IN RATS
Autore:
SUGAHARA H;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT PHYSIOL,N 15 W 7,KITA KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 3, volume: 43, anno: 1993,
pagine: 209 - 218
SICI:
0165-1838(1993)43:3<209:TVDEBV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; ATROPINE-RESISTANT VASODILATION; AIRWAY BLOOD-FLOW; NEUROGENIC INFLAMMATION; BRONCHIAL CIRCULATION; SALIVARY-GLAND; SENSORY NERVES; CO-EXISTENCE; NASAL-MUCOSA; CAT;
Keywords:
RAT; TRACHEA; BLOOD FLOW; VASODILATION; VAGAL NERVE; ELECTRICAL STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
H. Sugahara, "TRACHEAL VASCULAR DILATATION ELICITED BY VAGAL NERVE-STIMULATION IN RATS", Journal of the autonomic nervous system, 43(3), 1993, pp. 209-218

Abstract

We investigated the effects of the electrical stimulation of a unilateral cervical vagal nerve on the blood flow in the trachea using laserDoppler flowmetry in urethane anesthetized Wistar King rats. Stimulation for 30 s at 1, 2, 5, 10, 20 or 50 Hz with 10 V intensity caused anincrease in tracheal blood flow (TBF) in a frequency-dependent manner; the effects were most dominant with the 10-Hz stimulation among the six frequencies used. The increased responses of TBF with the muscarinic receptor antagonist atropine (1.0 mg/kg, iv.) were significantly reduced when compared with those without atropine at 5 Hz stimulation (123.3 +/- 11.9% vs. 180.1 +/- 24.5%). This shows the existence of vasodilation due to a cholinergic mechanism. The increased responses of TBFafter the ganglion blocking agent hexamethonium (20 mg/kg) iv. administration were significantly reduced when compared with those without hexamethonium at 1, 2 Hz stimulation (1 Hz: 18.9 +/- 2.7% vs. 35.4 +/- 4.7%, 2 Hz: 40.5 +/- 8.9% vs. 58.8 +/- 6.7%); this shows the existenceof vasodilation due to a non-cholinergic parasympathetic efferent mechanism which itself appears to be due to the release of neuropeptides such as VIP and PHI. The increased responses after hexamethonium administration were augmented probably because of the enhanced release of other neuropeptides like SP and CGRP especially at 10 Hz and 20 Hz stimulation. These findings suggest that the mechanism of vasodilation by the activity in the vagal fibers in the trachea of the rat has cholinergic and non-cholinergic efferent components and a non-cholinergic afferent component. In rats, the afferent component may play an importantrole in controlling tracheal vascular changes.

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Documento generato il 28/11/20 alle ore 09:51:57