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Titolo:
EFFECTS OF THE ANTIGLUCOCORTICOID RU-38486 ON THE INDUCTION OF LEARNED HELPLESS BEHAVIOR IN SPRAGUE-DAWLEY RATS
Autore:
PAPOLOS DF; EDWARDS E; MARMUR R; LACHMAN HM; HENN FA;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT,PROGRAM BEHAV GENET BRONX NY 10461 UNIV MARYLAND,DEPT PHARMACOL & TOXICOL BALTIMORE MD 21201 SUNY,DEPT PSYCHIAT STONY BROOK NY 11794
Titolo Testata:
Brain research
fascicolo: 2, volume: 615, anno: 1993,
pagine: 304 - 309
SICI:
0006-8993(1993)615:2<304:EOTARO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; GLUCOCORTICOID RECEPTOR; NERVOUS-SYSTEM; ANIMAL-MODELS; BRAIN; HIPPOCAMPUS; CORTICOSTERONE; ADRENALECTOMY; DEPRESSION; AUTORADIOGRAPHY;
Keywords:
ANTIGLUCOCORTICOID; LEARNED HELPLESSNESS; RU-38486; DENTATE GYRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
D.F. Papolos et al., "EFFECTS OF THE ANTIGLUCOCORTICOID RU-38486 ON THE INDUCTION OF LEARNED HELPLESS BEHAVIOR IN SPRAGUE-DAWLEY RATS", Brain research, 615(2), 1993, pp. 304-309

Abstract

Learned helplessness (LH) is induced by exposure to an inescapable oruncontrollable stressor which results in an inability to escape or avoid the same stressor when subsequently presented in a different context. In order to understand which central mechanisms may influence the expression of the learned helpless phenotype, we have pursued an experimental approach that seeks to elucidate the behavioral effects of glucocorticoid (GC) hormones in this animal model of depression. We have previously shown that the induction of LH behavior is enhanced by adrenalectomy, an effect that is reversed by corticosterone. In this study, our aim was to attempt to locate CNS sites responsible for the observed effects of glucocorticoids on learned helpless behavior by introducing the type II GC receptor antagonist, RU 38486 to discrete brain regions. We did not observe a significant effect in LH with acute systemic, acute dentate gyrus or intracerebroventricular injection of RU 38486 in contrast to previous studies using the Porsolt swim test, another animal model of depression. However, we were able to observe a significant change upon chronic administration to the dentate gyrus. These findings suggest that glucocorticoids exert a long-term influence on stress-induced behavior, presumably by affecting glucocorticoid responsive genes in the dentate gyrus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 09:52:35