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Titolo:
AUTORADIOGRAPHIC COMPARISON OF THE DISTRIBUTION OF [H-3] MK801 AND [H-3] CNQX IN THE HUMAN CEREBELLUM DURING DEVELOPMENT AND AGING
Autore:
JOHNSON M; PERRY EK; INCE PG; SHAW PJ; PERRY RH;
Indirizzi:
NEWCASTLE GEN HOSP,MRC,NEUROCHEM PHARMACOL UNIT,WESTGATE RD NEWCASTLETYNE NE4 6BE TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,MRC,NEUROCHEM PHARMACOL UNIT,WESTGATE RD NEWCASTLETYNE NE4 6BE TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,DEPT NEUROPATHOL NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND UNIV NEWCASTLE UPON TYNE,DEPT NEUROL NEWCASTLE TYNE NE1 7RU TYNE & WEAR ENGLAND UNIV NEWCASTLE UPON TYNE,DEPT PATHOL NEWCASTLE TYNE NE1 7RU TYNE & WEAR ENGLAND
Titolo Testata:
Brain research
fascicolo: 2, volume: 615, anno: 1993,
pagine: 259 - 266
SICI:
0006-8993(1993)615:2<259:ACOTDO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; CENTRAL-NERVOUS-SYSTEM; METHYL-D-ASPARTATE; GLUTAMATE-BINDING-SITES; ISCHEMIC BRAIN-DAMAGE; H-3 MK801 BINDING; RAT CEREBELLUM; SYNAPTIC PLASTICITY; NMDA RECEPTORS; AMPA RECEPTORS;
Keywords:
CEREBELLAR CORTEX; HUMAN; MK801; CNQX; GLUTAMATE RECEPTOR; DEVELOPMENT; AGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Johnson et al., "AUTORADIOGRAPHIC COMPARISON OF THE DISTRIBUTION OF [H-3] MK801 AND [H-3] CNQX IN THE HUMAN CEREBELLUM DURING DEVELOPMENT AND AGING", Brain research, 615(2), 1993, pp. 259-266

Abstract

The autoradiographic distribution of N-methyl-D-aspartate (NMDA) and -a-amino-3-hydroxyl-5-methyl-4-isoxazoleproprionic acid/quisqualate (AMPA/QUIS) receptors was determined in cerebellum obtained at autopsy from 37 human individuals, aged from 24 weeks gestation to 95 years. [H-3]MK801 was used to label the NMDA receptor and [H-3]CNQX to label the AMPA/QUIS receptor. AMPA/QUIS receptors were concentrated in the cerebellar molecular layer, and NMDA receptors in the granular layer. Significant (3- to 4-fold) increases in binding were seen for both ligands from the fetal to neonatal periods in the molecular layer (CNQX) andin both molecular and granular layers (MK801). MK801 binding in the molecular layer continued to increase with age up to the tenth decade and together with binding in the granular layer, increased 2-fold between 10-40 years. The Purkinje cell layer was negative for MK801 bindinguntil the 6-7th decade when it became positive. [H-3]CNQX binding in the molecular layer increased significantly with age between the fetalperiod and the tenth decade, whereas in the granular layer binding increased from neonate to 40 years, but then decreased significantly from 60 years to the the tenth decade. Lamination of the molecular and granular layers was absent during the fetal period and appeared with both ligands during the neonatal period. These marked differences in age-related expression of ligand binding sites in the granular layer during development and aging are of potential significance in relation bothto selective vulnerability to ischaemia, and synaptic plasticity and remodelling related to neuronal loss in senescence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:11:31