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Titolo:
RELATIONSHIP BETWEEN AMINO-ACID-TRANSPORT AND PROTEIN-SYNTHESIS IN RAT ISOLATED PANCREATIC ACINI UNDER STIMULATION WITH CHOLECYSTOKININ
Autore:
KOIZUMI T; BAMBA T; HOSODA S;
Indirizzi:
SHIGA UNIV MED SCI,DEPT INTERNAL MED 2,TSUKINOWA CHO OTSU SHIGA 52021JAPAN
Titolo Testata:
Gastroenterologia Japonica
fascicolo: 3, volume: 28, anno: 1993,
pagine: 385 - 392
SICI:
0435-1339(1993)28:3<385:RBAAPI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Keywords:
AMINO ACID TRANSPORT; SYSTEM-A; SYSTEM-L; PROTEIN SYNTHESIS; CHOLECYSTOKININ, ISOLATED RAT PANCREATIC ACINI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
T. Koizumi et al., "RELATIONSHIP BETWEEN AMINO-ACID-TRANSPORT AND PROTEIN-SYNTHESIS IN RAT ISOLATED PANCREATIC ACINI UNDER STIMULATION WITH CHOLECYSTOKININ", Gastroenterologia Japonica, 28(3), 1993, pp. 385-392

Abstract

The effects of cholecystokinin octapeptide (CCK8) on amino acid transport and protein synthesis in the pancreatic acini were determined. The question of whether those effects differed between amino acid transport systems A and L was also investigated. The influx of alpha-[H-3]aminoisobutyric acid (AIB, system A) and [C-14]cycloleucine (system L) into isolated rat pancreatic acini and the incorporation of [C-14]alanine (system A) and [H-3]leucine (system L) into trichloroacetic acid (TCA)-precipitable protein in pancreatic acini were studied in the presence of various concentrations of CCK8. CCK inhibited the amino acid transport across the basolateral membrane of pancreatic acini. This effect was mediated by Ca2+, and was more responsive to amino acid transport system L than to A. CCK also inhibited protein synthesis in pancreatic acini in a dose-dependent manner. The inhibition of protein synthesis by CCK was thought to be mainly due to the inhibition of amino acid transport by CCK. Therefore, the predominant utilization of extracellular amino acids in protein synthesis was suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:55:43