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Titolo:
ANTIHYPERTENSIVE EFFECT OF CHRONIC IV ADMINISTRATION OF 5-CARBOXAMIDOTRYPTAMINE IN SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
BALASUBRAMANIAM G; LEE HS; MAH SC;
Indirizzi:
NATL UNIV SINGAPORE,FAC MED,DEPT PHARMACOL,10 KENT RIDGE CRESCENT SINGAPORE 0511 SINGAPORE NATL UNIV SINGAPORE,FAC MED,DEPT PHARMACOL,10 KENT RIDGE CRESCENT SINGAPORE 0511 SINGAPORE CIBA GEIGY AG,DEPT MED CH-4002 BASEL SWITZERLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 237, anno: 1993,
pagine: 207 - 213
SICI:
0014-2999(1993)237:2-3<207:AEOCIA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONERGIC RECEPTORS; 5-HT1-LIKE RECEPTOR; VENA-CAVA; 5-HYDROXYTRYPTAMINE; AGONIST; ANTAGONIST; INHIBITION; 8-OH-DPAT; RELEASE; 5-HT1A;
Keywords:
5-CARBOXAMIDOTRYPTAMINE; 5-HT(1) RECEPTOR AGONISTS; SPONTANEOUSLY HYPERTENSIVE RATS (SHR); BLOOD PRESSURE (SYSTOLIC); BAROREFLEX SENSITIVITY; (CHRONIC INFUSION);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G. Balasubramaniam et al., "ANTIHYPERTENSIVE EFFECT OF CHRONIC IV ADMINISTRATION OF 5-CARBOXAMIDOTRYPTAMINE IN SPONTANEOUSLY HYPERTENSIVE RATS", European journal of pharmacology, 237(2-3), 1993, pp. 207-213

Abstract

The effects of chronic i.v. administration of the serotonin 5-HT1 receptor agonist, 5-carboxamidotryptamine (5-CT), on blood pressure (BP),heart rate (HR) and baroreflex sensitivity were studied in Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Acute i.v. injection of increasing doses of 5-CT resulted in a dose-dependent reduction in mean arterial pressure (MAP) in SHR and WKY with concomitant tachycardia. In chronic experiments, 5-CT (15.0 mug/kg per day) or vehicle (24.0 mul/day) was infused i.v. for 7 days, using osmotic minipumps. Systolic blood pressure (SBP) and HR were monitored daily before and during infusions. In SHR (n = 8) and WKY rats (n = 9) receiving 5-CT, a significant reduction in SBP was observed during the infusion period. HR was slightly increased in WKY rats on days 1 and 2. There were no HRchanges in the SHR group. The fall in SBP was significantly larger inthe SHR than in the WKY rats. Baroreflex sensitivity on day 7 was significantly greater in 5-CT-treated SHR than in control rats. There wasno change in baroreflex sensitivity in WKY rats. Administration of a single dose of 5-CT (0.5 mug/kg i.v.) on day 7 of infusion resulted inattenuated responses in WKY rats while SHR responded as their respective controls. Our data suggest that chronic administration of 5-CT results in a sustained antihypertensive effect. This is associated with an improved BRS in the SHR either as a consequence of a resetting of the baroreflex due to sustained lowering of BP or a direct action of 5-CT on baroreflex sensitivity. Our data also show that the vasodepressormechanism of 5-HT may be enhanced in SHR.

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Documento generato il 04/07/20 alle ore 21:25:54