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Titolo:
AN INVESTIGATION INTO THE ROLE OF WATER-MOVEMENT AND MUCUS GEL DEHYDRATION IN MUCOADHESION
Autore:
MORTAZAVI SA; SMART JD;
Indirizzi:
UNIV PORTSMOUTH,SCH PHARM & BIOMED SCI,DRUG DELIVERY RES UNIT PORTSMOUTH ENGLAND UNIV PORTSMOUTH,SCH PHARM & BIOMED SCI,DRUG DELIVERY RES UNIT PORTSMOUTH ENGLAND
Titolo Testata:
Journal of controlled release
fascicolo: 3, volume: 25, anno: 1993,
pagine: 197 - 203
SICI:
0168-3659(1993)25:3<197:AIITRO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESIVE;
Keywords:
MUCOADHESION; BIOADHESION; MUCUS DEHYDRATION; POLYACRYLIC ACID; BIORHEOLOGY; TENSIOMETER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Mortazavi e J.D. Smart, "AN INVESTIGATION INTO THE ROLE OF WATER-MOVEMENT AND MUCUS GEL DEHYDRATION IN MUCOADHESION", Journal of controlled release, 25(3), 1993, pp. 197-203

Abstract

Water transfer between mucoadhesive formulations and mucus gels was investigated. The water uptake by compacts and gels, measured in terms of weight gain, was evaluated at 37-degrees-C by placing each onto a section of dialysis membrane which was then placed in contact with a sample of porcine gastric mucus. Water transfer occurred for all the dry(and concentrated gel) formulations and was evident after only 1 min,with anionic polymers dehydrating the mucus gel more than the neutralpolymer. As the concentration of gels containing Carbopol 934P decreased, so the extent of water uptake decreased, with water being lost from the 4% gels. The effect of dehydration on the physical properties of the mucus gel was evaluated using a modified tensiometer and dynamicoscillatory rheology. The adhesive and cohesive nature of the mucus gel was seen to increase when the water content decreased, which would be predicted to result in the strengthening of the weakest component of a mucoadhesive joint. It was concluded that water movement would be a significant factor in mucoadhesion involving dry and partially hydrated dosage forms, and this may be more important than molecular interpenetration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:22:28