Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CIGARETTE-SMOKING DURING PREGNANCY LOWERS AROMATASE CYTOCHROME-P-450 IN THE HUMAN PLACENTA
Autore:
KITAWAKI J; INOUE S; TAMURA T; YAMAMOTO T; HONJO H; HIGASHIYAMA T; OSAWA Y; OKADA H;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT OBSTET & GYNECOL KYOTO 602 JAPAN MED FDN BUFFALO INC,RES INST BUFFALO NY 14203
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 6, volume: 45, anno: 1993,
pagine: 485 - 491
SICI:
0960-0760(1993)45:6<485:CDPLAC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIRTH-WEIGHT; ASSAY; MOTHERS; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J. Kitawaki et al., "CIGARETTE-SMOKING DURING PREGNANCY LOWERS AROMATASE CYTOCHROME-P-450 IN THE HUMAN PLACENTA", Journal of steroid biochemistry and molecular biology, 45(6), 1993, pp. 485-491

Abstract

To clarify whether cigarette smoking during pregnancy causes an organic alteration in placental estrogen producing ability, we determined the catalytic activity of aromatase by the tritiated water assay, and tissue level of aromatase cytochrome P-450 (P450arom) by the specific enzyme-linked immunosorbent assay, in placental samples from nonsmokersand smokers. As pregnancy progressed, both aromatase activity and P-450arom concentration increased in placentas from nonsmokers and smokers. However, the gradient of the increase was significantly less in heavy smokers (greater-than-or-equal-to 20 cigarettes a day) than in normal and moderate smokers (<20 cigarettes a day). At term, the mean aromatase activity and P-450arom concentration in placentas from heavy smokers were significantly lower than in nonsmokers and moderate smokers,while aromatase activity per P-450arom (turnover rate) and the mean placental weight were comparable among the three groups. In contrast, the ratio of aryl hydrocarbon hydroxylase activity to aromatase activity was higher in placentas from heavy smokers. Immunohistochemical studies showed that P450arom was localized in the cytoplasm of syncytiotrophoblasts of chorionic villi in placentas from both nonsmokers and smokers. These results suggest that the induction of placental P-450arom during gestation is suppressed by maternal smoking, resulting in a reduction in estrogen producing ability, while placental xenobiotic P-450is induced.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:50:35