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Titolo:
REGIONAL BLOOD-BRAIN LACTATE INFLUX
Autore:
LAMANNA JC; HARRINGTON JF; VENDEL LM; ABISALEH K; LUST WD; HARIK SI;
Indirizzi:
CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROL,10900 EUCLID AVE,368-1144 CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV HOSP,DEPT NEUROL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV HOSP,EXPTL NEUROSURG LAB CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROSCI CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS CLEVELAND OH44106
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 614, anno: 1993,
pagine: 164 - 170
SICI:
0006-8993(1993)614:1-2<164:RBLI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARRIER TRANSPORT; ACID TRANSPORT; KETONE-BODIES; RATS; GLUCOSE; CONSTANTS; CARRIER;
Keywords:
BLOOD BRAIN BARRIER; LACTATE TRANSPORT; MONOCARBOXYLATE ANION CARRIER; TRANSPORT KINETICS; RAT BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Lamanna et al., "REGIONAL BLOOD-BRAIN LACTATE INFLUX", Brain research, 614(1-2), 1993, pp. 164-170

Abstract

Regional blood-to-brain lactate transport was studied in chloral hydrate anesthetized rats using the single pass, dual-label, indicator fractionation, right atrial injection method. Lactate influx was resolvedinto two components, a saturable, stereospecific (to the L-enantiomer) component and a non-saturable, non-stereospecific diffusional component. The saturable component was found to have a low efficiency and moderate capacity with transport affinity coefficients between 6 and 14 mM and transport maxima of 23-40 mumol/100 g/min in the various brain regions. Lactate transport was not inhibited by probenecid. The diffusional component was determined from D-lactate influx measurements and the regional linear diffusion coefficients ranged from 0.020 to 0.036 ml/g/min. At the usual levels of plasma lactate (1-1.5 mM) these two influx components were about equal. The relative contribution of the non-stereospecific diffusional component was increased at higher plasma lactate concentrations. Lactate clearance, estimated by the total apparent permeability x surface area products was between 6 and 8 ml/100 g/min.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:10:36