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Titolo:
ACTH(4-9) ANALOG ORG-2766 CAN IMPROVE EXISTING NEUROPATHY IN STREPTOZOCIN-INDUCED DIABETIC RATS
Autore:
BRAVENBOER B; KAPPELLE AC; VANBUREN T; ERKELENS DW; GISPEN WH;
Indirizzi:
UNIV UTRECHT,RUDOLF MAGNUS INST,DEPT MED PHARMACOL,VONDELLAAN 6 3521 GD UTRECHT NETHERLANDS UNIV UTRECHT,RUDOLF MAGNUS INST,DEPT MED PHARMACOL,VONDELLAAN 6 3521 GD UTRECHT NETHERLANDS UNIV UTRECHT,RUDOLF MAGNUS INST,DEPT INTERNAL MED 3521 GD UTRECHT NETHERLANDS
Titolo Testata:
Acta diabetologica
fascicolo: 1, volume: 30, anno: 1993,
pagine: 21 - 24
SICI:
0940-5429(1993)30:1<21:AAOCIE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY MYOINOSITOL SUPPLEMENTATION; CISPLATIN-INDUCED NEUROTOXICITY; NERVE CONDUCTION-VELOCITY; K+-ATPASE ACTIVITY; SCIATIC-NERVE; PREVENTION; GLYCOSYLATION;
Keywords:
ACTH(4-9); EXPERIMENTAL DIABETIC NEUROPATHY; NEUROPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
B. Bravenboer et al., "ACTH(4-9) ANALOG ORG-2766 CAN IMPROVE EXISTING NEUROPATHY IN STREPTOZOCIN-INDUCED DIABETIC RATS", Acta diabetologica, 30(1), 1993, pp. 21-24

Abstract

The effect of treatment of an existing neuropathy in streptozocin-induced diabetic rats with the ACTH4-9 analogue ORG 2766 was examined. Four groups of rats were studied: group 1 consisted of age-matched, non-diabetic controls and groups 2, 3 and 4 of diabetic rats. Sensory and motor nerve conduction velocity (SNCV and MNCV) were measured at weeks0, 4, 6, 8 and 10. Four weeks after the administration of streptozocin (STZ) all diabetic rats showed a significant slowing of SNCV and MNCV. Treatment was then started: group 2 was treated with placebo, group3 with a low dos (1 mug) of ACTH4-9 subcutaneously every 48 h, and group 4 with a high dos (10 mug) of ACTH4-9 subcutaneously every 48 h. The animals treated with the high peptide dosage showed a significant improvement in both SNCV and MNCV from week 6 onwards, whereas this beneficial effect was not demonstrated for the rats treated with the low dosage. This study demonstrates that the ACTH4-9 analogue ORG 2766 canameliorate existing diabetic neuropathy in STZ-induced diabetic rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:44:35