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Titolo:
COLLAGEN AND ELASTIN IN RABBIT FETAL LUNG - ONTOGENY AND EFFECTS OF STEROIDS
Autore:
ANCESCHI MM; PALMERINI CA; CODINI M; LUZI P; COSMI EV;
Indirizzi:
POLICLIN UMBERTO-I,INST OBSTET & GINECOL 2,VIALE REGINA ELENA 324 I-00161 ROME ITALY UNIV PERUGIA,DEPT EXPTL MED & BIOCHEM SCI I-06100 PERUGIA ITALY UNIV ROMA LA SAPIENZA,INST OBSTET & GYNAECOL 2 I-00185 ROME ITALY
Titolo Testata:
Journal of developmental physiology
fascicolo: 5, volume: 18, anno: 1992,
pagine: 233 - 236
SICI:
0141-9846(1992)18:5<233:CAEIRF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRETERM RABBITS; RAT; CORTICOSTEROIDS; MATURATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Anceschi et al., "COLLAGEN AND ELASTIN IN RABBIT FETAL LUNG - ONTOGENY AND EFFECTS OF STEROIDS", Journal of developmental physiology, 18(5), 1992, pp. 233-236

Abstract

Ontogeny of lung collagen and elastin were studied in fetal rabbit from day 25 to term. Collagen (isolated by hot trichloroacetic acid treatment) and elastin (contained in the residue) were hydrolyzed and the hydroxyproline and desmosine quantitated by hplc. Hydroxyproline slightly increased from day 25 to day 30 (204 to 244 mug/100g dry weight). Over the same period desmosine increased from 2.2 to 5.1 mug/100 mg dry weight (P<0.01). The effect of antenatal corticosteroids on the lungof prematurely-delivered fetuses was also evaluated. Betamethasone (B) was given to pregnant does at a dose of 0.2 mg/kg 24 and 48 h beforedelivery of the fetuses at 26, 27 and 28 days. In treated animals elastin concentration increased significantly by about 22% on day 26 (P=0.05), by 29% on day (P<0.02) and by 47% on day 28 (P<0.02). Hydroxyproline was not affected by steroid treatment at any gestational age. This suggests that steroids affect fetal lung development also via changes in connective tissue.

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Documento generato il 11/08/20 alle ore 15:48:57