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Titolo:
CHOLINERGIC TRANSMITTER AND NEUROTROPHIC ACTIVITIES IN LEWY BODY DEMENTIA - SIMILARITY TO PARKINSON AND DISTINCTION FROM ALZHEIMER-DISEASE
Autore:
PERRY EK; IRVING D; KERWIN JM; MCKEITH IG; THOMPSON P; COLLERTON D; FAIRBAIRN AF; INCE PG; MORRIS CM; CHENG AV; PERRY RH;
Indirizzi:
UNIV NEWCASTLE,NEWCASTLE GEN HOSP,BRIGHTON CLIN,DEPT NEUROPATHOL,MRC,NEUROCHEM PATHOL UNIT NEWCASTLE TYNE NE4 6BE ENGLAND UNIV NEWCASTLE,NEWCASTLE GEN HOSP,BRIGHTON CLIN,DEPT OLD AGE PSYCHIATNEWCASTLE TYNE NE4 6BE ENGLAND BENSHAM GEN HOSP GATESHEAD ENGLAND
Titolo Testata:
Alzheimer disease and associated disorders
fascicolo: 2, volume: 7, anno: 1993,
pagine: 69 - 79
SICI:
0893-0341(1993)7:2<69:CTANAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; SENILE DEMENTIA; ACETYLTRANSFERASE ACTIVITY; BASAL FOREBRAIN; HIPPOCAMPUS; NEURONS; IMMUNOREACTIVITY; ABNORMALITIES; FEATURES; SUBTYPES;
Keywords:
CHOLINE ACETYLTRANSFERASE; NERVE GROWTH FACTOR RECEPTOR; MUSCARINIC AND NICOTINIC RECEPTORS; HALLUCINATIONS; CEREBRAL CORTEX; MEYNERT NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
E.K. Perry et al., "CHOLINERGIC TRANSMITTER AND NEUROTROPHIC ACTIVITIES IN LEWY BODY DEMENTIA - SIMILARITY TO PARKINSON AND DISTINCTION FROM ALZHEIMER-DISEASE", Alzheimer disease and associated disorders, 7(2), 1993, pp. 69-79

Abstract

Senile dementia of Lewy body type or Lewy body dementia (LBD), characterized neuropathologically by the presence of Lewy bodies in the brainstem and cortex, and in most cases neocortical senile plaques (but few or no tangles), bears a closer resemblance to Parkinson's (PD) than to Alzheimer disease (AD) in its cholinergic neurochemical pathology. Thus, reductions in the biochemical activity of choline acetyltransferase were generally more extensive in neo- as opposed to archicortical regions in LBD (especially hallucinating cases) and in PD, whereas muscarinic receptor binding was significantly increased in LBD and PD butnot in AD. Nerve growth factor receptor (P75) assessed immunocytochemically in the archicortex were decreased in PD and, to a lesser extent, in LBD in conjunction with reductions of neuronal numbers in the nucleus of Meynert (Ch4), but were relatively spared in AD. These observations indicate that although AD is primarily associated with dysfunction of cholinergic axonal input to the cortex, LBD and PD are more likely to involve degeneration of the basal forebrain cholinergic system. Relevance of the findings in terms of aetiopathology and cholinergic treatment strategies is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:51:43