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Titolo:
DETERMINATION OF THE ENANTIOMERIC PURITY OF 5,6-DIHYDROXY-2-AMINOTETRALINS AND 6,7-DIHYDROXY-2-AMINOTETRALINS BY CHIRAL HPLC
Autore:
CASTELNOVO P;
Indirizzi:
ZAMBON RES,MED CHEM LAB,VIA DEL DUCA 10 BRESSO ITALY
Titolo Testata:
Chirality
fascicolo: 3, volume: 5, anno: 1993,
pagine: 181 - 187
SICI:
0899-0042(1993)5:3<181:DOTEPO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOST-GUEST COMPLEXATION; AMINO-ACIDS; ESTER SALTS; SEPARATION; CHROMATOGRAPHY; RECOGNITION; RESOLUTION;
Keywords:
ENANTIOMERS; DIRECT SEPARATION; 2-AMINOTETRALINS; DOPAMINE RECEPTOR AGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
P. Castelnovo, "DETERMINATION OF THE ENANTIOMERIC PURITY OF 5,6-DIHYDROXY-2-AMINOTETRALINS AND 6,7-DIHYDROXY-2-AMINOTETRALINS BY CHIRAL HPLC", Chirality, 5(3), 1993, pp. 181-187

Abstract

5,6- and 6,7-Dihydroxy-2-aminotetralin (ADTN), racemic dopamine receptor agonists, were resolved into their enantiomers by a new chiral HPLC assay. The separation was performed on a Crownpack CR column, which contains an 18-crown-6-type chiral crown ether as a chiral selector. The chiral recognition is based on the complexation of the protonated primary amino group and the oxygen atoms inside the cavity of the crownether. The amino group is attached to the chiral centre and thereforethese compounds could be resolved. Mobile phase was perchloric acid pH 2.0 and the detection was UV at 200 nm. Resolution factors were 3.1 for 5,6-ADTN and 1.1 for 6,7-ADTN resulting in very low limits of quantitation (<0.1%) of the enantiomer present as impurity. Data on the validation of the assay and on the stability of the column are also reported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:38:36