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Titolo:
CATENINS IN XENOPUS EMBRYOGENESIS AND THEIR RELATION TO THE CADHERIN-MEDIATED CELL-CELL ADHESION SYSTEM
Autore:
SCHNEIDER S; HERRENKNECHT K; BUTZ S; KEMLER R; HAUSEN P;
Indirizzi:
MAX PLANCK INST ENTWICKLUNGSBIOL,SPEMANNSTR 35-V W-7400 TUBINGEN GERMANY MAX PLANCK INST ENTWICKLUNGSBIOL,SPEMANNSTR 35-V W-7400 TUBINGEN GERMANY MAX PLANCK INST IMMUNBIOL W-7800 FREIBURG GERMANY
Titolo Testata:
Development
fascicolo: 2, volume: 118, anno: 1993,
pagine: 629 - 640
SICI:
0950-1991(1993)118:2<629:CIXEAT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULE E-CADHERIN; CYTOPLASMIC DOMAIN; EPITHELIAL-CELLS; EXPRESSION; PROTEIN; UVOMORULIN; EMBRYOS; LAEVIS; VINCULIN; HOMOLOG;
Keywords:
CATENIN; CADHERIN; CELL ADHESION; EMBRYOGENESIS; XENOPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S. Schneider et al., "CATENINS IN XENOPUS EMBRYOGENESIS AND THEIR RELATION TO THE CADHERIN-MEDIATED CELL-CELL ADHESION SYSTEM", Development, 118(2), 1993, pp. 629-640

Abstract

In the course of an analysis of cell-cell adhesion in the Xenopus embryo, antibodies directed against alpha- and beta-catenin were applied to investigate their relation to the cadherins occurring early in thissystem. The results demonstrate that alpha- and beta-catenin are provided maternally and increase in amount throughout embryogenesis. Immunoprecipitations indicate that both of the catenins are complexed to U-cadherin in the early phase of embryogenesis and to F-cadherin, when it appears during gastrulation. An excess of alpha-catenin occurs in free form in the early embryo, whereas all of the beta-catenin seems to be complexed to cadherin. Synthesis of the two components throughout early embryogenesis and their binding to newly synthesized cadherins were demonstrated by metabolic labelling. The spatial distribution of alpha-catenin was analysed by immunohistology. During cleavage alpha-catenin is deposited evenly along the plasma membranes within the embryo,while the cell peripheries at the surface of the embryo remain devoidof alpha-catenin. At later stages, the pattern of alpha-catenin distribution becomes more complex. Quantitative differences in the intensity of staining along the plasma membranes in the different regions of the embryo can be distinguished. Particularly the appearance of E-cadherin in the gastrula ectoderm is accompanied by conspicous depositions of alpha-catenin along the respective plasma membranes in this layer. All cells in the later embryo, apart from the neural crest cells, carry alpha-catenin on their plasma membranes indicating the universal character of cadherin-mediated cell-cell adhesion in the Xenopus embryo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:13:31