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Titolo:
IMPORTANCE OF INTERFERONS IN RECOVERY FROM MOUSEPOX
Autore:
KARUPIAH G; FREDRICKSON TN; HOLMES KL; KHAIRALLAH LH; BULLER RML;
Indirizzi:
NIAID,VIRAL DIS LAB BETHESDA MD 20892 NIAID,VIRAL DIS LAB BETHESDA MD 20892 NCI,REGISTRY EXPTL CANC BETHESDA MD 20892 UNIV CONNECTICUT,DEPT PHYSIOL & NEUROBIOL STORRS CT 06292 NIAID,BIOL RESOURCES BRANCH BETHESDA MD 20892
Titolo Testata:
Journal of virology
fascicolo: 7, volume: 67, anno: 1993,
pagine: 4214 - 4226
SICI:
0022-538X(1993)67:7<4214:IOIIRF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ECTROMELIA VIRUS-INFECTION; VACCINIA VIRUS; T-CELLS; MONOCLONAL-ANTIBODY; ANTIVIRAL ACTIVITY; MICE; GAMMA; RESISTANCE; INHIBITION; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
G. Karupiah et al., "IMPORTANCE OF INTERFERONS IN RECOVERY FROM MOUSEPOX", Journal of virology, 67(7), 1993, pp. 4214-4226

Abstract

Gamma interferon is shown to be critical in recovery of C57BL/6 mice from mousepox. Anti-gamma interferon treatment of mice infected in thefootpad with ectromelia virus resulted in enhanced spread to and efficient virus replication in the spleen, lungs, ovaries, and, especially, liver. All treated, infected mice died within a mean of 7 days, 2.5 days earlier than mice with severe combined immunodeficiency that weregiven a comparable infection. On the other hand, alpha interferon appeared not to have a major role in controlling virus replication in tissues examined, and beta interferon was important for virus clearance in the liver and ovaries but not the spleen. Either anti-alpha, beta interferon or anti-beta interferon antibody therapy resulted in only 25%mortality. Infected control mice survived but showed persistence of ectromelia virus at the site of infection (the footpad) and transient presence of the virus in the spleen, liver, lungs, and ovaries and in the fibroreticular but not lymphoid cells of the draining popliteal lymph node. Depletion of gamma interferon but not alpha and/or beta interferon resulted in a significant reduction in the numbers of splenic T (especially gammdelta-TCR+), B, and Mac-1+ cells, although the proportion of Mac-l+ cells in the spleen increased compared with control values. Depletion of alpha, beta, or gamma interferons did not severely affect the generation of virus-specific cytotoxic T-lymphocyte responsesor natural killer cell cytolytic activity. This study, in which a natural virus disease model was used, underscores the crucial importance of gamma interferon in virus clearance at all stages of infection and in all tissues tested except the primary site of infection, where virus clearance appears to be delayed.

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Documento generato il 29/11/20 alle ore 10:19:38