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Titolo:
BETA-AMYLOID PRECURSOR PROTEIN MESSENGER-RNA IS INCREASED IN INCLUSION-BODY MYOSITIS MUSCLE
Autore:
SARKOZI E; ASKANAS V; JOHNSON SA; ENGEL WK; ALVAREZ RB;
Indirizzi:
UNIV SO CALIF,CTR NEUROMUSCULAR,DEPT NEUROL,637 S LUCAS AVE LOS ANGELES CA 90017 UNIV SO CALIF,CTR NEUROMUSCULAR,DEPT NEUROL,637 S LUCAS AVE LOS ANGELES CA 90017 UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR LOS ANGELES CA 90089
Titolo Testata:
NeuroReport
fascicolo: 6, volume: 4, anno: 1993,
pagine: 815 - 818
SICI:
0959-4965(1993)4:6<815:BPPMII>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; BRAIN; CDNA;
Keywords:
BETA-APP MESSENGER RNA; MUSCLE FIBERS; INCLUSION BODY MYOSITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E. Sarkozi et al., "BETA-AMYLOID PRECURSOR PROTEIN MESSENGER-RNA IS INCREASED IN INCLUSION-BODY MYOSITIS MUSCLE", NeuroReport, 4(6), 1993, pp. 815-818

Abstract

VACUOLATED muscle fibers in muscle biopsies of 8 out of 8 inclusion body myositis (IBM) patients, including 2 hereditary patients, manifested increased mRNA for the beta-amyloid precursor protein (betaAPP) that contains Kunitz-type protease inhibitor motif. In affected fibers, increased betaAPP-mRNA corresponded to abnormally accumulated betaAPP immunoreactivity (including beta-amyloid protein epitope). In normal human muscle fibers increased betaAPP-mRNA was present only at the neuromuscular junctions. Our study (a) suggests that abnormally accumulatedbetaAPP in IBM vacuolated fibers results, at least partly, from increased betaAPP generation, and (b) provides the first demonstration of up-regulated betaAPP-mRNA in pathologic human tissue other than brain of Alzheimer's disease and Down's syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:16:14