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Titolo:
FATAL BRAIN-STEM NECROSIS AFTER STANDARD POSTERIOR-FOSSA RADIATION AND AGGRESSIVE CHEMOTHERAPY FOR METASTATIC MEDULLOBLASTOMA
Autore:
WATTERSON J; SIMONTON SC; RORKE LB; PACKER RJ; KIM TH; SPIEGEL RH; PRIEST JR;
Indirizzi:
CHILDRENS HOSP,DEPT HEMATOL ONCOL,ROOM 1100 ST PAUL MN 55102 CHILDRENS HOSP,DEPT PATHOL ST PAUL MN 00000 CHILDRENS HOSP PHILADELPHIA,DEPT PATHOL PHILADELPHIA PA 00000 ABBOTT NW HOSP,VIRGINIA PIPER CANC INST,DEPT RADIAT ONCOL MINNEAPOLISMN 00000 CHILDRENS HOSP,NATL MED CTR,DEPT NEUROL WASHINGTON DC 20010 CHILDRENS HOSP,NATL MED CTR,DEPT PEDIAT WASHINGTON DC 20010
Titolo Testata:
Cancer
fascicolo: 12, volume: 71, anno: 1993,
pagine: 4111 - 4117
SICI:
0008-543X(1993)71:12<4111:FBNASP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; HIGH-DOSE CISPLATIN; DISSEMINATED TESTICULAR CANCER; PRIOR CRANIAL IRRADIATION; 2 DOSAGE SCHEDULES; COMBINATION CHEMOTHERAPY; CIS-DIAMMINEDICHLOROPLATINUM; CHILDHOOD LEUKEMIA; HYPERTONIC SALINE; PHASE-II;
Keywords:
RADIATION NECROSIS; MEDULLOBLASTOMA; CISPLATIN; METHOTREXATE; EXTRANEURAL RECURRENCE; RADIATION TOXICITY; COMBINED RADIOCHEMOTHERAPY TOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
J. Watterson et al., "FATAL BRAIN-STEM NECROSIS AFTER STANDARD POSTERIOR-FOSSA RADIATION AND AGGRESSIVE CHEMOTHERAPY FOR METASTATIC MEDULLOBLASTOMA", Cancer, 71(12), 1993, pp. 4111-4117

Abstract

A 3-year-old girl received conventional-dose external beam posterior fossa irradiation (5400 cGy in 30 fractions over 40 days) for good-risk medulloblastoma. Soon thereafter, she experienced an extraneural (occipital scar, cervical lymph nodes) and central nervous system (CNS) recurrence. Intensive cisplatin and cyclophosphamide chemotherapy led to rapid disappearance of the extraneural disease. Methotrexate was administered via a ventricular reservoir. After 2 months of chemotherapy,CNS toxicity progressed rapidly from ataxia to paraplegia to quadriplegia to central respiratory failure. Radiographic scans and autopsy material revealed brain stem necrosis. This unusual toxicity raises concern about the safety of aggressive systemic chemotherapy and intrathecal therapy, when given after conventional radiotherapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:21:39