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Titolo:
INCREASED LIPOPROTEIN (A) AND ITS RELATIONSHIPS WITH OTHER PARAMETERSOF LIPOPROTEIN METABOLISM IN CHRONIC-RENAL-FAILURE TREATED BY HEMODIALYSIS
Autore:
YIGITOGLU MR; POLAT MF; AKCAY F; ARI Z; UYANIK BS; OZILGILI HM;
Indirizzi:
CELAL BAYER UNIV,SCH MED,DEPT BIOCHEM MANISA TURKEY
Titolo Testata:
Japanese Heart Journal
fascicolo: 1, volume: 38, anno: 1997,
pagine: 83 - 89
SICI:
0021-4868(1997)38:1<83:IL(AIR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; SERUM; RISK; ATHEROSCLEROSIS; LP(A);
Keywords:
APOLIPOPROTEINS; LIPOPROTEIN (A); CHRONIC RENAL FAILURE AND HEMODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Yigitoglu et al., "INCREASED LIPOPROTEIN (A) AND ITS RELATIONSHIPS WITH OTHER PARAMETERSOF LIPOPROTEIN METABOLISM IN CHRONIC-RENAL-FAILURE TREATED BY HEMODIALYSIS", Japanese Heart Journal, 38(1), 1997, pp. 83-89

Abstract

Background. Studies have shown that patients with chronic renal failure have a high frequency of cardiocascular atheromatous disease. Methods. We examined serum lipoprotein (a) [Lp(a)], very-low density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), apolipoprotein Al (ape Al) and B (ape B), triglyceride (TG) and total cholesterol (TC) levels as possible risk factors for atherosclerosis in 4-5 patients with chronic renal failure (CRE) treated by hemodialysis (HD) and in 15 CRF patients who were not on HD. A control group of 20 healthy subjectswas also studied. Results. The proportion of smokers and body mass indexes were similar between the groups. In both patient groups, higher TG, TC and Lp(a) and lower apo Al and HDL-C levels in serum were foundthan in those of controls. Serum apo B and LDL-C were similar in the patients treated by HD and the controls. Serum VLDL-C and LDL-C were similar in the CRF patients who were not on HD and the controls. The highest ratios of apo B/apo Al and LDL-C/HDL-C were found in HD patients. The highest ratio of TC/HDL-C was found in the other patient group. We found significant correlations between Lp(a) and other parameters of lipoprotein metabolism in CRF patients, both those who were and those who were not on HD. Conclusions. Our results indicate that CRF patients who both were and were not on HD show atherogenic changes in the lipoprotein pattern, and that the increase in Lp(a) during the CRF phase is basically related to the loss of renal function and may also depend on the resultant alterations which are produced in other lipoprotein variables.

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Documento generato il 16/07/20 alle ore 06:33:11