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Titolo:
ABSORPTION, ELIMINATION AND METABOLIC-FATE OF BUNAZOSIN IN 3 HEALTHY MALE-VOLUNTEERS
Autore:
MORISHITA N; TOMONO Y; HASEGAWA J; YUZURIHA T; GIESE U;
Indirizzi:
EISAI & CO LTD,CTR CLIN PHARMACOL & BIOSTAT,KOISHIKAWA 4-6-10,BUNKYO KU TOKYO 11288 JAPAN
Titolo Testata:
Drug investigation
fascicolo: 6, volume: 5, anno: 1993,
pagine: 296 - 301
SICI:
0114-2402(1993)5:6<296:AEAMOB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
N. Morishita et al., "ABSORPTION, ELIMINATION AND METABOLIC-FATE OF BUNAZOSIN IN 3 HEALTHY MALE-VOLUNTEERS", Drug investigation, 5(6), 1993, pp. 296-301

Abstract

Investigation of the metabolism of C-14-bunazosin (2.0mg) in 3 healthy male volunteers indicated that the primary route of metabolism of this alpha1-adrenoceptor antagonist, as for other quinazoline derivatives, is via demethylation and hydroxylation. Of the total radioactivity administered, 37% was recovered in the urine and 58% in the faeces over the 7-day period postdose. Urinary radioactivity was accounted for by metabolites (96%). predominantly bunazosin-N-glucuronide and unidentified polar compounds, and a small amount of unchanged bunazosin (4%). Faecal radioactivity was due to unchanged bunazosin (11%) and a variety of metabolites, including 6- and 7-desmethylbunazosin and unidentified polar compounds. O-glucuronides were present in similar amounts inthe urine and faeces, whereas N-glucuronides were more abundant in the urine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:50:17