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Titolo:
DURATION-DEPENDENT CHANGES IN CALCIUM RESPONSIVENESS IN THE ALLOXAN-DIABETIC RAT INTESTINE
Autore:
OZTURK Y; ALTAN VM; YILDIZOGLUARI N;
Indirizzi:
ANADOLU UNIV,FAC PHARM,DEPT PHARMACOL TR-26470 TEPEBASI ESKISEHIR TURKEY
Titolo Testata:
Journal of diabetes and its complications
fascicolo: 5, volume: 10, anno: 1996,
pagine: 288 - 293
SICI:
1056-8727(1996)10:5<288:DCICRI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RESPONSES; GASTRIC-ACID SECRETION; AUTONOMIC NEUROPATHY; SMOOTH-MUSCLE; GASTROINTESTINAL COMPLICATIONS; CONTRACTILE RESPONSES; STREPTOZOTOCIN; INSULIN; MELLITUS; DUODENUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ozturk et al., "DURATION-DEPENDENT CHANGES IN CALCIUM RESPONSIVENESS IN THE ALLOXAN-DIABETIC RAT INTESTINE", Journal of diabetes and its complications, 10(5), 1996, pp. 288-293

Abstract

Disturbances of the gastrointestinal tract that are common in diabetes mellitus seem to be related to intestinal motility. In experimental models of diabetes, decreased calcium sensitivity has been demonstrated in various smooth muscles including those in the gastrointestinal tract. The main purpose of the present study was to examine further the calcium sensitivity in diabetic rat intestine and to understand if changes in the calcium sensitivity occur at an earlier stage of the disease, For this purpose, the effects of potassium and calcium were evaluated on nondepolarized and depolarized duodenum from rats with alloxan diabetes for 1 and 8 weeks and their age-matched controls. To evaluatethe calcium sensitivity in rat duodenum, apparent affinity constants (pD(2) values) and intrinsic activities (alpha(E) values) were calculated for every experimental conditions examined in this study, Both values (pD(2) and alpha(E)) for the effects of potassium and calcium on the nondepolarized and depolarized duodenum, respectively, were not, changed in 1-week diabetic rats. In contrast, intrinsic activities for the effects of potassium and calcium were found to be significantly decreased (p < 0.001) in the nondepolarized and depolarized duodenum fromrats with alloxan diabetes for 8 weeks, whereas apparent affinity constants were not altered in this case. Taking into consideration all these experimental findings, the decreased calcium sensitivity in gastrointestinal tract seems to be closely related to decreased calmodulin levels and may occur at a later stage of diabetes as a linkage to long-term gastrointestinal complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 11:13:12