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Titolo:
CHARACTERIZATION AND DISTRIBUTION OF PHAGOCYTIC MACROPHAGES IN MULTIPLE-SCLEROSIS PLAQUES
Autore:
LI H; NEWCOMBE J; GROOME NP; CUZNER ML;
Indirizzi:
INST NEUROL,MULTIPLE SCLEROSIS SOC LAB,1 WAKEFIELD ST LONDON WC1N 1PJENGLAND OXFORD BROOKES UNIV,SCH BIOL & MOLEC SCI OXFORD ENGLAND
Titolo Testata:
Neuropathology and applied neurobiology
fascicolo: 3, volume: 19, anno: 1993,
pagine: 214 - 223
SICI:
0305-1846(1993)19:3<214:CADOPM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; HUMAN MONONUCLEAR PHAGOCYTES; MONOCLONAL-ANTIBODIES; DENDRITIC CELLS; PATHOLOGY; LESION;
Keywords:
MULTIPLE SCLEROSIS; MACROPHAGES; MICROGLIA; MONOCYTES; HLA-DQ; MYELIN BASIC PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Li et al., "CHARACTERIZATION AND DISTRIBUTION OF PHAGOCYTIC MACROPHAGES IN MULTIPLE-SCLEROSIS PLAQUES", Neuropathology and applied neurobiology, 19(3), 1993, pp. 214-223

Abstract

Populations of phagocytic cells in multiple sclerosis (MS) plaques were examined by quantitative immunocytochemical analysis of macrophage markers and myelin degradation products in serial cryostat sections from 10 cases of MS. Around lesions with ongoing demyelination expression of the Class II antigen HLA-DQ appeared to be a marker of microglialactivation. Alpha 1-antichymotrypsin+ monocytes and myelin-laden macrophages expressing the later differentiation markers Ber-MAC3 and RFD7were predominantly perivascular in location. On the basis of the distribution of oil red 0 (ORO)+ phagocytes and myelin loss, plaques were divided into groups representing different stages in lesion development. In early lesions (group 1), there was no apparent myelin loss around ORO+ macrophages although these cells contained material stained with antibodies against myelin basic protein (MBP) epitopes and neoepitopes. However, patchy myelin loss was detectable around the phagocytic macrophages uniformly distributed throughout group 2 plaques. ORO+ macrophages containing MBP peptides were confined to the hypercellular border of group 4 lesions, in which the demyelinating process may be recurrent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 18:18:16