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Titolo:
EFFECT OF ACUTE MONOAMINE DEPLETION ON 3,4-METHYLENEDIOXYMETHAMPHETAMINE-INDUCED NEUROTOXICITY
Autore:
BRODKIN J; MALYALA A; NASH JF;
Indirizzi:
PROCTER & GAMBLE CO,SHARON WOODS TECH CTR,HB BLDG,BOX 249,11511 REED HARTMAN HIGHWAY CINCINNATI OH 45241 CASE WESTERN RESERVE UNIV,SCH MED,DEPT PSYCHIAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,SCH MED,DEPT NEUROSCI CLEVELAND OH 44106
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 3, volume: 45, anno: 1993,
pagine: 647 - 653
SICI:
0091-3057(1993)45:3<647:EOAMDO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIALLY OXIDIZED SEROTONIN; H-3 PAROXETINE BINDING; RAT-BRAIN; PARA-CHLOROAMPHETAMINE; DOPAMINE RELEASE; INVIVO MICRODIALYSIS; METHYLENEDIOXYMETHAMPHETAMINE; MDMA; STRIATUM; METABOLITES;
Keywords:
ALPHA-METHYL-P-TYROSINE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; MICRODIALYSIS; NEUROTOXICITY; P-CHLOROPHENYLALANINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J. Brodkin et al., "EFFECT OF ACUTE MONOAMINE DEPLETION ON 3,4-METHYLENEDIOXYMETHAMPHETAMINE-INDUCED NEUROTOXICITY", Pharmacology, biochemistry and behavior, 45(3), 1993, pp. 647-653

Abstract

The effect of acute, reversible depletion of either serotonin [5-hydroxytryptamine (5-HT)] or dopamine (DA) on the long-term (7-day) decrease of brain 5-HT content produced after 3,4-methylenedioxymethamphetamine (MDMA) administration was investigated. The tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine (alpha-MPT) significantly attenuated the acute increase in DA efflux produced by MDMA in the striatum as measured by in vivo microdialysis. Treatment with alpha-MPT had no effect on MDMA-induced 5-HT release. Alpha-MPT treatment blocked the long-term (7-day) depletion of striatal 5-HT content after MDMA administration. The tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA) completely blocked the acute increase in the extracellular concentration of 5-HT produced by MDMA. Although PCPA significantly attenuated the increase in DA efflux produced by MDMA, the effect was small in magnitude. More importantly, treatment with PCPA had no effect on MDMA-induced decrease of 5-HT uptake sites in the frontal cortex. These data are suggestive that acute depletion of DA but not 5-HT protects againstthe long-term neurotoxic effects of MDMA on 5-HT axon terminals. In addition, these data are supportive of the hypothesis that DA plays a major role in the neurotoxic effects of MDMA.

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Documento generato il 20/01/21 alle ore 02:14:27