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Titolo:
A SYSTEM FOR MEASURING ELECTROPHYSIOLOGICAL MULTIPLE-UNIT ACTIVITY AND EXTRACELLULAR DOPAMINE CONCENTRATION AT SINGLE ELECTRODES
Autore:
GLYNN GE; YAMAMOTO BK;
Indirizzi:
NE OHIO UNIV,COLL MED,DEPT PHARMACOL,2800 PLYMOUTH RD ROOTSTOWN OH 44272 CASE WESTERN RESERVE UNIV,DEPT PSYCHIAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT NEUROSCI CLEVELAND OH 44106
Titolo Testata:
Journal of neuroscience methods
fascicolo: 3, volume: 47, anno: 1993,
pagine: 235 - 246
SICI:
0165-0270(1993)47:3<235:ASFMEM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASCORBIC-ACID; AMPHETAMINE; INCREASES; INVIVO; VOLTAMMETRY; STRIATUM; NEURONS;
Keywords:
DOPAMINE; INVIVO VOLTAMMETRY; MULTIPLE-UNIT ACTIVITY; ELECTROPHYSIOLOGY; BASAL GANGLIA; STRIATUM; AMPHETAMINE; PARGYLINE; ALPHA-METHYL-PARA-TYROSINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
G.E. Glynn e B.K. Yamamoto, "A SYSTEM FOR MEASURING ELECTROPHYSIOLOGICAL MULTIPLE-UNIT ACTIVITY AND EXTRACELLULAR DOPAMINE CONCENTRATION AT SINGLE ELECTRODES", Journal of neuroscience methods, 47(3), 1993, pp. 235-246

Abstract

A technique is described for measuring electrophysiological multiple-unit activity and extracellular dopamine concentration with in vivo voltammetry at an array of 8 electrodes. In addition, new procedures in the construction of the voltammetric electrode that reduce the effectsof capacitance and improve sensitivity are outlined. A system of relays controlling the connections of the electrode and associated systemsis also detailed. Both in vitro and in vivo voltammetric selectivity tests indicate an almost exclusive response to dopamine. A large increase in extracellular dopamine concentration was detected in response to 2.5 mg/kg D-amphetamine. Both prestimulus and cortical stimulation evoked increases in striatal multiple-unit activity were measured.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:49:19