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Titolo:
NORADRENALINE DEPLETION EXACERBATES MPTP-INDUCED STRIATAL DOPAMINE LOSS IN MICE
Autore:
MARIEN M; BRILEY M; COLPAERT F;
Indirizzi:
CTR RECH PIERRE FABRE,DIV NEUROBIOL,17 AVE JEAN MOULIN F-81106 CASTRES FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 236, anno: 1993,
pagine: 487 - 489
SICI:
0014-2999(1993)236:3<487:NDEMSD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS; PARKINSONS-DISEASE; RAT; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; NEUROTOXICITY; PROJECTIONS; NEURONS; LESIONS; DSP4;
Keywords:
PARKINSONS DISEASE; LOCUS-CERULEUS; MPTP (1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE); STRIATAL DOPAMINE; SP-4(N-(2-CHLOROETHYL)-N-ETHYL-2-BROMOBENZYLAMINE); C57B1/6 MOUSE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M. Marien et al., "NORADRENALINE DEPLETION EXACERBATES MPTP-INDUCED STRIATAL DOPAMINE LOSS IN MICE", European journal of pharmacology, 236(3), 1993, pp. 487-489

Abstract

Injection of C57Bl/6 mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 4 X 10 mg/kg i.p. over 8 h) resulted in a partial (40%) striatal dopamine depletion at 7 days post-drug. Pretreatment with theselective noradrenergic neurotoxin N-[2-chloroethyl]-N-ethyl-2-bromobenzylamine (DSP-4; 40 mg/kg i.p.), while having no effect per se on striatal dopamine levels, exacerbated the MPTP-induced dopamine deficit to 60%. Results support the hypothesis that damage to the locus coeruleus-noradrenergic system, by removing a facilitatory influence on the nigrostriatal dopamine system, interferes with the ability of the nigrostriatal pathway to compensate for or recover from injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 12:29:29