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Titolo:
FACTORS AFFECTING SHORT-TERM AND LONG-TERM STABILITIES OF PROTEINS
Autore:
ARAKAWA T; PRESTRELSKI SJ; KENNEY WC; CARPENTER JF;
Indirizzi:
AMGEN INC,AMGEN CTR,1830 DE HAVILLAND DR THOUSAND OAKS CA 91320 UNIV COLORADO,HLTH SCI CTR,SCH PHARM DENVER CO 80262
Titolo Testata:
Advanced drug delivery reviews
fascicolo: 1, volume: 10, anno: 1993,
pagine: 1 - 28
SICI:
0169-409X(1993)10:1<1:FASALS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASED THERMAL-STABILITY; FREEZE-DRIED LIPOSOMES; CALF BRAIN TUBULIN; PREFERENTIAL INTERACTIONS; RIBONUCLEASE-A; POLY(ETHYLENE GLYCOLS); SOLVENT DENATURATION; ENHANCED PROTECTION; BETA-LACTOGLOBULIN; DIVALENT-CATIONS;
Keywords:
PROTEIN STABILIZATION; FREEZE-INDUCED DENATURATION; LYOPHILIZATION-INDUCED DENATURATION; PROTEIN DEGRADATION; CRYOPROTECTANT; CO-SOLUTE INDUCED STABILIZATION OF PROTEINS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
113
Recensione:
Indirizzi per estratti:
Citazione:
T. Arakawa et al., "FACTORS AFFECTING SHORT-TERM AND LONG-TERM STABILITIES OF PROTEINS", Advanced drug delivery reviews, 10(1), 1993, pp. 1-28

Abstract

Proteins are marginally stable and hence readily denatured by variousstresses encountered in solution, or in the frozen or dried states. Various additives are known to minimize the damage and to enhance the stability of proteins. This review discusses the current knowledge of the mechanisms by which these additives stabilize proteins against acute stresses, and also the various factors to be considered for long-term storage of proteins in solution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:52:42