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Titolo:
FORMATION OF 18-DEOXY-19-NORALDOSTERONE BY A HUMAN ALDOSTERONE-PRODUCING ADENOMA
Autore:
TAKEDA Y; IKI K; MIYAMORI I; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,TAKARA MACHI 13-1 KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Steroids
fascicolo: 6, volume: 58, anno: 1993,
pagine: 282 - 285
SICI:
0039-128X(1993)58:6<282:FO1BAH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
18-HYDROXY-19-NORCORTICOSTERONE; 18,19-DIHYDROXYCORTICOSTERONE; 19-NOR-DEOXYCORTICOSTERONE;
Keywords:
STEROIDS; 18-DEOXY-19-NORALDOSTERONE; 19-NORALDOSTERONE; ALDOSTERONE-PRODUCING ADENOMA; ADRENAL TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "FORMATION OF 18-DEOXY-19-NORALDOSTERONE BY A HUMAN ALDOSTERONE-PRODUCING ADENOMA", Steroids, 58(6), 1993, pp. 282-285

Abstract

The recently synthesized 18-deoxy-19-noraldosterone is a potent aldosterone antagonist. In the present study we demonstrate the in vitro formation of 18-deoxy-19-noraldosterone from 19-noraldosterone in a human aldosterone-producing adenoma and normal adrenal tissue. The metabolite was isopolar, cochromatographed with the authentic standard on high-performance liquid chromatography, and the identity was further analyzed by mass spectrometry. The possible role of 18-deoxy-19-noraldosterone in primary aldosteronism is also discussed.

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Documento generato il 01/12/20 alle ore 10:14:46