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Titolo:
FENOLDOPAM MESYLATE VERSUS SODIUM-NITROPRUSSIDE IN THE ACUTE MANAGEMENT OF SEVERE SYSTEMIC HYPERTENSION
Autore:
PILMER BL; GREEN JA; PANACEK EA; ELLIOT WJ; MURPHY MB; RUTHERFORD W; NARA AR;
Indirizzi:
UNIV HOSP CLEVELAND,UCRC 2,ROOM 110,11001 CEDAR AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT MED,DIV CARDIOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT MED,DIV CRIT CARE MED CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT EMERGENCY MED CLEVELAND OH 44106 UNIV CHICAGO,COMM CLIN PHARMACOL CHICAGO IL 60637
Titolo Testata:
Journal of clinical pharmacology
fascicolo: 6, volume: 33, anno: 1993,
pagine: 549 - 553
SICI:
0091-2700(1993)33:6<549:FMVSIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONIST FENOLDOPAM; BLOOD-PRESSURE REDUCTION; INTRAVENOUS FENOLDOPAM; HEART-FAILURE; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Pilmer et al., "FENOLDOPAM MESYLATE VERSUS SODIUM-NITROPRUSSIDE IN THE ACUTE MANAGEMENT OF SEVERE SYSTEMIC HYPERTENSION", Journal of clinical pharmacology, 33(6), 1993, pp. 549-553

Abstract

Thirty-three patients with severe systemic hypertension defined as a diastolic blood pressure (DBP) greater-than-or-equal-to 120 mm Hg wererandomized in a single-blind fashion to be treated with either intravenous fenoldopam mesylate (FNP) or sodium nitroprusside (NTP). Fenoldopam mesylate and NTP infusion rates began at 0.1 mug/kg/minute and 0.5mug/kg/minute, respectively and were titrated to achieve a goal DBP of between 95 and 110 mm Hg; or a reduction of at least 40 mm Hg if thebaseline DBP was > 150 mm Hg. Fenoldopam mesylate (n = 15) reduced blood pressure from 217/145 +/- 6/5 to 187/112 +/- 6/3 mm Hg (P < .001) at an average infusion rate of 0.5 +/- 0.1 mug/kg/minute. The average time to achieve goal DBP with FNP was 1.5 +/- 1.4 hours. Nitroprusside(n = 18) reduced blood pressure from 210/136 +/- 5/2 to 172/103 +/- 6/2 mum Hg (P < .001) at an average infusion rate of 1.2 +/- .24 mug/kg/minute. Nitroprusside response time averaged 2 +/- 2.5 hours. There was no significant difference between the magnitude of effect seen witheither FNP or NTP; nor was there any difference observed in the adverse effect rates of the two agents. Fenoldopam mesylate and NTP demonstrate similar overall efficacy in the treatment of severe systemic hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:24:01