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Titolo:
TEMPORAL-LOBE HYPOMETABOLISM ON PET - PREDICTOR OF SEIZURE CONTROL AFTER TEMPORAL LOBECTOMY
Autore:
RADTKE RA; HANSON MW; HOFFMAN JM; CRAIN BJ; WALCZAK TS; LEWIS DV; BEAM C; COLEMAN RE; FRIEDMAN AH;
Indirizzi:
DUKE UNIV,MED CTR,DIV NEUROL,POB 2905 DURHAM NC 27710 DUKE UNIV,MED CTR,DIV NUCL MED DURHAM NC 27710 DUKE UNIV,MED CTR,DIV NEUROPATHOL DURHAM NC 27710 DUKE UNIV,MED CTR,DIV NEUROSURG DURHAM NC 27710
Titolo Testata:
Neurology
fascicolo: 6, volume: 43, anno: 1993,
pagine: 1088 - 1092
SICI:
0028-3878(1993)43:6<1088:THOP-P>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL EPILEPSY; PATHOLOGICAL FINDINGS; MR; LATERALIZATION; TOMOGRAPHY; VOLUME; FOCI; EEG; CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Radtke et al., "TEMPORAL-LOBE HYPOMETABOLISM ON PET - PREDICTOR OF SEIZURE CONTROL AFTER TEMPORAL LOBECTOMY", Neurology, 43(6), 1993, pp. 1088-1092

Abstract

To investigate the relationship of temporal lobe hypometabolism demonstrated on PET to surgical outcome and underlying pathology, we reviewed 30 consecutive epilepsy patients who underwent interictal PET studies with F-18 fluorodeoxyglucose before temporal lobectomy. Two interpreters blindly reviewed the PET studies and graded them for degree, extent, and location of temporal lobe hypometabolism. Pathologic analysisof en bloc resected tissue showed mesial temporal sclerosis (n = 22),astrocytoma (n = 2), and no pathologic diagnosis (n = 6). Outcome (24to 40 months' follow-up) was rated as seizure-free (21 patients), significantly improved (five patients), and not significantly improved (four patients). Both the degree and extent of the temporal lobe hypometabolism demonstrated on PET were strongly associated with subsequent seizure control. Pathologic findings, however, did not correlate with degree of PET hypometabolism or subsequent outcome. These data demonstrate that in patients judged to have temporal lobe epilepsy, the presence of temporal lobe hypometabolism is associated with a positive outcome after ipsilateral temporal lobectomy.

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Documento generato il 29/09/20 alle ore 04:36:12