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Titolo:
A SIMPLE SYNTHESIS OF [C-11] DIHYDROTETRABENAZINE (DTBZ)
Autore:
JEWETT DM; KILBOURN MR; LEE LC;
Indirizzi:
UNIV MICHIGAN,SCH MED,DEPT INTERNAL MED,DIV NUCL MED,3480 KRESGE 3 ANN ARBOR MI 48109
Titolo Testata:
Nuclear medicine and biology
fascicolo: 2, volume: 24, anno: 1997,
pagine: 197 - 199
SICI:
0969-8051(1997)24:2<197:ASSO[D>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESICULAR MONOAMINE TRANSPORTER; POSITRON EMISSION TOMOGRAPHY; C-11 TETRABENAZINE; HUMAN-BRAIN; PET;
Keywords:
[C-11] DIHYDROTETRABENAZINE; VESICULAR MONOAMINE TRANSPORTER; DTBZ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Jewett et al., "A SIMPLE SYNTHESIS OF [C-11] DIHYDROTETRABENAZINE (DTBZ)", Nuclear medicine and biology, 24(2), 1997, pp. 197-199

Abstract

[C-11]Dihydrotetrabenazine 3-isobutyl-9-[C-11]methoxy-10-methoxy-1,2,3,4,6,7, -hexahydro-11bH-benzo[a]-quinolizine) ([C-11]DTBZ) was synthesized by re-acting the 9-hydroxy precursor in DMSO with gas phase [C-11]methyl iodide on a column of alumina impregnated with KOH. The reaction was instantaneous at room temperature. This column was then connected to the inlet of a short column containing basic alumina. Elution with cyclohexane removed radioactive contaminants. The radioactive product was then eluted with a few milliliters ether containing 1% ethanol. The [C-11]DTBZ was obtained in isolated yields of >200 mCi and specific activities >1600 Ci/mmol. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:22:04