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Titolo:
THE EFFECTS OF PROSTACYCLIN ANALOG OP-41483 ON NORMOTHERMIC LIVER ISCHEMIA AND REPERFUSION INJURY IN RATS
Autore:
ABE T; LYNCH S; BALDERSON G; PILLAY P; AKIYAMA T; INUZUKA S; MATSUNAMI H; STRONG R;
Indirizzi:
FUKUSHIMA MED COLL,DEPT SURG 1,1 BANCHI,HIKARIGAOKA FUKUSHIMA FUKUSHIMA 96012 JAPAN QUEENSLAND LIVER TRANSPLANT SERV BRISBANE QLD AUSTRALIA
Titolo Testata:
Prostaglandins, leukotrienes and essential fatty acids
fascicolo: 6, volume: 48, anno: 1993,
pagine: 417 - 422
SICI:
0952-3278(1993)48:6<417:TEOPAO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-I2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
T. Abe et al., "THE EFFECTS OF PROSTACYCLIN ANALOG OP-41483 ON NORMOTHERMIC LIVER ISCHEMIA AND REPERFUSION INJURY IN RATS", Prostaglandins, leukotrienes and essential fatty acids, 48(6), 1993, pp. 417-422

Abstract

To estimate the effects of the prostacyclin analog (OP-41483) on normothermic liver ischemia and reperfusion injury, saline (Group 1, N = 8), heparin (group 2, N = 8, 100 u/kg) or OP-41483 (group 3, N = 8, 400ng/kg/min) was infused intravenously for 30 min before and after liver ischemia in rats. There were no significant differences in survival,or transaminase at 30 min after reperfusion among the three groups. Hepatic vessel flow and tissue flow were measured for the first 30 min after reperfusion. Hepatic tissue now increased for the first 30 min after reperfusion in the group 3 rats, but not in the groups 2 and 3 rats. There were significant differences in hepatic tissue flow between the groups 1 and 3 rats at 20 min (p < 0.05), as well as significant differences between the groups 1 and 3 rats (p < 0.01) and the groups 1and 2 rats (p < 0.05) at 30 min after reperfusion. There were no significant differences in total hepatic inflow among the three groups. Our data suggest that OP-41483 exerts beneficial effects by improving the microcirculation and increasing the effective hepatic blood flow in the ischemically injured liver after reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 01:21:15