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Titolo:
DOPAMINERGIC INFLUENCE ON THE EXCITABILITY OF ANTIDROMICALLY ACTIVATED RENSHAW CELLS IN THE LUMBAR SPINAL-CORD OF THE RAT
Autore:
MAITRA KK; SETH P; THEWISSEN M; ROSS HG; GANGULY DK;
Indirizzi:
INDIAN INST CHEM BIOL,DIV PHARMACOL & EXPTL THERAPEUT,4 RAJA SC MULLICK RD CALCUTTA 700032 W BENGAL INDIA INDIAN INST CHEM BIOL,DIV PHARMACOL & EXPTL THERAPEUT,4 RAJA SC MULLICK RD CALCUTTA 700032 W BENGAL INDIA
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 2, volume: 148, anno: 1993,
pagine: 101 - 107
SICI:
0001-6772(1993)148:2<101:DIOTEO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RELEASE; NUCLEUS ACCUMBENS; MOTOR-NERVE; MODULATION; RECEPTOR; AUTORECEPTORS; TRANSMISSION;
Keywords:
APOMORPHINE; DOPAMINERGIC MODULATION; POSTTETANIC POTENTIATION; RENSHAW CELLS; SULPIRIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K.K. Maitra et al., "DOPAMINERGIC INFLUENCE ON THE EXCITABILITY OF ANTIDROMICALLY ACTIVATED RENSHAW CELLS IN THE LUMBAR SPINAL-CORD OF THE RAT", Acta Physiologica Scandinavica, 148(2), 1993, pp. 101-107

Abstract

The interaction between dopaminergic and cholinergic systems in the mammalian central nervous system, which is thought to have important implications in the pathophysiology of major extrapyramidal disorders, has never been adequately demonstrated in vivo. Renshaw cell burst responses to single electrical shocks to lumbar ventral roots in spinalized and decerebrated rats were studied. In this monosynaptic cholinergicpathway, apomorphine, a dopaminergic receptor agonist, inhibited whereas the D2-antagonist sulpiride facilitated the burst responses. The mutual antagonism of the two drugs and the depression coupled with the faster decay of post-tetanic potentiation of Renshaw cells by apomorphine demonstrate the involvement of presynaptic D2-receptors through which dopamine can modulate acetylcholine-mediated central synaptic transmission in vivo. The study also provides further evidence for the involvement of the spinal cord in extrapyramidal disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:55:25