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Titolo:
SPERMICIDAL AND ANTIVIRAL PROPERTIES OF CHOLIC-ACID - CONTRACEPTIVE EFFICACY OF A NEW VAGINAL SPONGE (PROTECTAID(R)) CONTAINING SODIUM CHOLATE
Autore:
PSYCHOYOS A; CREATSAS G; HASSAN E; GEORGOULIAS V; GRAVANIS A;
Indirizzi:
HOP BICETRE,INSERM,80 RUE GEN LECLERC F-94276 LE KREMLIN BICETR FRANCE ALEXANDRA MATERN HOSP,ATHENS MED SCH,DEPT OBSTET & GYNAECOL 1 GR-11528 ATHENS GREECE UNIV CRETE,SCH MED,DEPT PHARMACOL GR-71110 IRAKLION GREECE
Titolo Testata:
Human reproduction
fascicolo: 6, volume: 8, anno: 1993,
pagine: 866 - 869
SICI:
0268-1161(1993)8:6<866:SAAPOC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONOXYNOL-9;
Keywords:
CHOLIC ACID; CONTRACEPTIVE VAGINAL SPONGE; HUMAN IMMUNODEFICIENCY VIRUS (HIV); SEXUALLY TRANSMITTED DISEASE (STD); SPERMICIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Psychoyos et al., "SPERMICIDAL AND ANTIVIRAL PROPERTIES OF CHOLIC-ACID - CONTRACEPTIVE EFFICACY OF A NEW VAGINAL SPONGE (PROTECTAID(R)) CONTAINING SODIUM CHOLATE", Human reproduction, 8(6), 1993, pp. 866-869

Abstract

Cholic acid (sodium cholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity. The same effects are observed for F-5 Gel(R), the active mixture of a new contraceptive sponge (Protectaid(R)), which contains sodium cholate in association with low concentrations (0.5%) of nonoxynol-9 and benzalkonium chloride. Both cholic acid and the F-5 Gel exert a dose-dependent, in-vitro inhibitory effect (i) on the activity of HIV-1 associated reverse transcriptase in an acellular system and (ii) on the potential of HIV-1 efficiently to infect human lymphocytes. During 12 months use, the contraceptive efficacy of the 'Protectaid(R), Sponge was 100% in 20 young women who had chosen this method for reasons of both contraception and anti-sexually transmitted disease. No side-effects were recorded throughout this period. Cervical cultures at 6-month intervals showed the presence of Mycoplasma hominis and Candida albicans in one or two cases. The combined spermicidal and anti-HIV properties of chotic acid reported in this paper and used in the 'Protectaid(R), Sponge offer a new and modern protective method of contraception.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:46:20