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Titolo:
SURFACTANT TREATMENT OF RESPIRATORY-FAILURE INDUCED BY HYDROCHLORIC-ACID ASPIRATION IN RATS
Autore:
EIJKING EP; GOMMERS D; SO KL; VERGEER M; LACHMANN B;
Indirizzi:
ERASMUS UNIV ROTTERDAM,DEPT ANESTHESIOL,ROOM EE2392,BOX 1738 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT ANESTHESIOL,ROOM EE2392,BOX 1738 3000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Anesthesiology
fascicolo: 6, volume: 78, anno: 1993,
pagine: 1145 - 1151
SICI:
0003-3022(1993)78:6<1145:STORIB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXOGENOUS SURFACTANT; DISTRESS SYNDROME; REPLACEMENT; PROTEIN; INACTIVATION; MEMBRANE; RABBITS; RISK;
Keywords:
LUNGS; ACID ASPIRATION; BRONCHOALVEOLAR LAVAGE; EXOGENOUS SURFACTANT THERAPY; RESPIRATORY FAILURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Eijking et al., "SURFACTANT TREATMENT OF RESPIRATORY-FAILURE INDUCED BY HYDROCHLORIC-ACID ASPIRATION IN RATS", Anesthesiology, 78(6), 1993, pp. 1145-1151

Abstract

Background: The surfactant system seems to be involved in the pathophysiology of respiratory failure caused by hydrochloric acid (HCI) aspiration. This study was an investigation of the effect of different treatment strategies using an exogenous surfactant preparation on lung function of rats suffering from respiratory failure after intratracheal HCl instillation. Methods. In rats anesthetized with halothane, nitrous oxide, and oxygen, tracheotomy was performed and the lungs were mechanically ventilated. Respiratory failure was induced by intratracheal instillation of HCI (0.1 N, 3 ml/kg). After the Pa(O2) decreased to <200 mmHg, the animals were randomly divided into five groups. Group I received no treatment; group II received a natural surfactant preparation intratracheally (200 mg/kg); group M underwent bronchoalveolar lavage (BAL) with saline, followed by surfactant treatment (200 mg/kg); and groups IV and V underwent BAL with saline and a diluted surfactant suspension (3.3 mg/ml in 30 ml/kg), respectively. Groups IV and V received a second and third BAL 60 and 120 min after the first lavage. Blood gas analysis and protein measurements in BAL fluids were performed. Results. Gas exchange improved in Groups III and V only. Protein concentrations were high in all BAL fluids. In the rats receiving BAL threetimes (groups IV and V), a decrease in protein concentration was observed. Conclusions. From these results, it was concluded that plasma-derived proteins (which are known to inhibit surfactant function) are washed out of the alveoli by BAL, resulting in improved efficacy of surfactant treatment.

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Documento generato il 05/07/20 alle ore 03:38:27