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Titolo:
PRESENCE AND SEVERITY OF CEREBRAL WHITE-MATTER LESIONS AND HYPERTENSION, ITS TREATMENT, AND ITS CONTROL - THE ARIC STUDY
Autore:
LIAO DP; COOPER L; CAI JW; TOOLE JF; BRYAN NR; HUTCHINSON RG; TYROLER HA;
Indirizzi:
UNIV N CAROLINA,SCH PUBL HLTH,DEPT EPIDEMIOL,137 E FRANKLIN ST,NATIONSBANK PLAZA,SUITE 306 CHAPEL HILL NC 27514 UNIV N CAROLINA,SCH PUBL HLTH,DEPT BIOSTAT CHAPEL HILL NC 27514 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT NEUROL WINSTON SALEM NC 27103 JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL BALTIMORE MD 21205 UNIV MISSISSIPPI,MED CTR,DEPT MED JACKSON MS 39216
Titolo Testata:
Stroke
fascicolo: 12, volume: 27, anno: 1996,
pagine: 2262 - 2270
SICI:
0039-2499(1996)27:12<2262:PASOCW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIVENTRICULAR LESIONS; CARDIOVASCULAR-DISEASE; RISK-FACTORS; ABNORMALITIES; ROTTERDAM; DECLINE; ADULTS; HEALTH; BRAIN; MRI;
Keywords:
EPIDEMIOLOGY; ETHNIC GROUPS; HYPERTENSION; WHITE MATTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
D.P. Liao et al., "PRESENCE AND SEVERITY OF CEREBRAL WHITE-MATTER LESIONS AND HYPERTENSION, ITS TREATMENT, AND ITS CONTROL - THE ARIC STUDY", Stroke, 27(12), 1996, pp. 2262-2270

Abstract

Background and Purpose White matter lesions (WML) may result from cerebral hypoperfusion or ischemia. We investigated the association of WML with blood pressure, hypertension, and its treatment and control. Methods A random sample of 1920 participants aged 55 to 72 years in the Atherosclerosis Risk in Communities Study (ARIC) was examined. Spin-density 1.5-T MRI scan images were coded from 0 for normal to 9 for mostsevere WML. Hypertension was defined as systolic or diastolic pressure greater than or equal to 140/90 mm Hg or use of antihypertensive medication. Results The percentages of persons with WML grades 0 through 2 and 3 through 9, respectively, were as follows: normotensive, 92.4% and 7.6%, versus all hypertensive subjects, 83% and 17% (P<.001); and treated controlled hypertensive, 86% and 14%, versus treated uncontrolled hypertensive subjects, 76% and 24% (P=.003). Multivariable adjusted odds ratios (95% confidence intervals) for WML grade greater than orequal to 3 relative to normotensive subjects was 2.34 (1.71 to 3.20) for all hypertensives, 1.99 (1.19 to 3.08) for untreated hypertensives, 1.94 (1.32 to 2.85) for treated controlled hypertensives, and 3.40 (2.30 to 5.03) for treated uncontrolled hypertensives. After additionaladjustment for hypertension duration, treatment, and control status, the odds ratios (95% confidence intervals) for a 1 SD increase of systolic and diastolic blood pressure were 1.43 (1.11 to 1.85) and 1.16 (0.94 to 1.43), respectively. Conclusions Hypertension is associated with increased odds of WML, and treated uncontrolled hypertensive subjects have greater odds of WML than those with treated controlled hypertension. The data suggest that the level of blood pressure, especially systolic blood pressure, is related to WML additional to the effects of categorically defined hypertension and its treatment and control status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 05:41:06