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Titolo:
MOLECULAR-GENETICS OF LACTATE-DEHYDROGENASES FROM LACTIC-ACID BACTERIA
Autore:
DELCOUR J; BERNARD N; GARMYN D; FERAIN T; HOLS P;
Indirizzi:
UNIV CATHOLIQUE LOUVAIN,UNITE GENET,CROIX SUD 5 B-1348 LOUVAIN BELGIUM
Titolo Testata:
Le Lait
fascicolo: 2, volume: 73, anno: 1993,
pagine: 127 - 131
SICI:
0023-7302(1993)73:2<127:MOLFLB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
FRE
Soggetto:
ESCHERICHIA-COLI; LACTOBACILLUS-CASEI; D-2-HYDROXYISOCAPROATE DEHYDROGENASE; STEREOSPECIFIC REDUCTION; 2-KETOCARBOXYLIC ACIDS; CLONING; EXPRESSION; ENZYME; CONFUSUS;
Keywords:
LACTATE-DEHYDROGENASE; HYDROXY-ISOCAPROATE DEHYDROGENASE; LACTIC ACID BACTERIA; LACTATE; LACTOBACILLUS-BULGARICUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
J. Delcour et al., "MOLECULAR-GENETICS OF LACTATE-DEHYDROGENASES FROM LACTIC-ACID BACTERIA", Le Lait, 73(2), 1993, pp. 127-131

Abstract

We have cloned 2 D-lactate-dehydrogenase genes (D-LDH) and one D-hydroxy-isocaproate-dehydrogenase gene (D-HicDH) from lactic acid bacteria(Lactobacillus delbrueckii subsp bulgaricus, Pediococcus acidilactici) by complementation of a LDH-negative mutant of Escherichia coli. Thesequence of these genes has revealed the existence of a novel family of NADH-dependent alpha-hydroxy-acid dehydrogenases which were completely different from the L-LDH family. The structure-function relationships of enzymes from this new family are currently under study via site-directed mutagenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 10:24:05